6971-57-9

Basic information

• Product Name: 6-METHYL-2-PICOLYL-METHYLAMINE
• Synonyms: methyl(6-methyl-2-pyridylmethyl)amine;N,6-Dimethyl-2-pyridinemethanamine;Methyl-(6-Methyl-pyridin-2-ylMethyl)-aMine;N-Methyl-N-[(6-methylpyridin-2-yl)methyl]amine;N-Methyl-1-(6-Methylpyridin-2-yl)MethanaMine;N-Methyl-1-(6-methylpyridin-2-yl)
• CAS NO: 6971-57-9
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.19428
• EINECS: 230-201-0
• Mol File: 6971-57-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 190.8±25.0℃ (760 Torr)
• Flash Point: 69.2±23.2℃
• Appearance: /
• Density: 0.968±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.53mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-METHYL-2-PICOLYL-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHYL-2-PICOLYL-METHYLAMINE(6971-57-9)
• EPA Substance Registry System: 6-METHYL-2-PICOLYL-METHYLAMINE(6971-57-9)

Safety Data

• Hazardous Substances Data: 6971-57-9(Hazardous Substances Data)

Usage

General Description

6-Methyl-2-picolyl-methylamine is a chemical compound used primarily in scientific research and chemical synthesis. Its chemical formula is C8H12N2 and it is also known by other names such as 6-METHYL-2-(METHYLAMINO)PYRIDINE and N-METHYL-6-METHYL-2-PYRIDINAMINE. 6-METHYL-2-PICOLYL-METHYLAMINE is a derivative of pyridine, characterised by the substitution of two of its hydrogen atoms with a methyl group and a picolyl group. Additionally, it is a secondary amine due to the presence of the amino group. Due to its structure, it can act as a ligand in coordination chemistry. It's essential to handle this chemical with care due to its reactivity and it's required to store it in a dry, cool place.

InChI:InChI=1/C8H12N2/c1-7-4-3-5-8(10-7)6-9-2/h3-5,9H,6H2,1-2H3

Upstream product

• 3099-30-7 2-chloromethyl-6-methylpyridine hydrochloride 
• 74-89-5 methylamine 
• 68470-59-7 2-(bromomethyl)-6-methylpyridine 
• 67-56-1 methanol 
• 332179-68-7 2-(azidomethyl)-6-methylpyridine 
• 1122-72-1 6-methyl-2-pyridinecarboxaldehyde 

Downstream Products

• 128739-26-4 2-[Methyl-(6-methyl-pyridin-2-ylmethyl)-amino]-2-phenyl-ethanol 
• 128739-03-7 N-<(6-methyl-2-pyridyl)methyl>-2-(methylamino)-1-phenyl-1-ethanol 
• 128739-09-3 N-<(6-methyl-2-pyridyl)methyl>-2-(methylamino)-1-phenyl-1-ethyl benzoate 
• 128739-07-1 1-(4-Methoxy-phenyl)-2-[methyl-(6-methyl-pyridin-2-ylmethyl)-amino]-ethanol 
• 128739-08-2 N-<(6-methyl-2-pyridyl)methyl>-2-(methylamino)-1-phenyl-1-ethyl acetate 
• 128739-06-0 1-(4-Chloro-phenyl)-2-[methyl-(6-methyl-pyridin-2-ylmethyl)-amino]-ethanol 
• 128739-24-2 Benzoic acid 2-[methyl-(6-methyl-pyridin-2-ylmethyl)-amino]-1-phenyl-ethyl ester; compound with (Z)-but-2-enedioic acid 
• 128751-64-4 Acetic acid 2-[methyl-(6-methyl-pyridin-2-ylmethyl)-amino]-1-phenyl-ethyl ester; compound with (Z)-but-2-enedioic acid 
• 128739-22-0 1-(4-Methoxy-phenyl)-2-[methyl-(6-methyl-pyridin-2-ylmethyl)-amino]-ethanol; compound with (E)-but-2-enedioic acid 
• 128739-21-9 1-(4-Chloro-phenyl)-2-[methyl-(6-methyl-pyridin-2-ylmethyl)-amino]-ethanol; compound with (E)-but-2-enedioic acid 
• 128739-19-5 2-[Methyl-(6-methyl-pyridin-2-ylmethyl)-amino]-1-phenyl-ethanol; compound with (Z)-but-2-enedioic acid 
• 128739-27-5 2-[Methyl-(6-methyl-pyridin-2-ylmethyl)-amino]-2-phenyl-ethanol; compound with (Z)-but-2-enedioic acid 
• 128739-25-3 2-[Methyl-(6-methyl-pyridin-2-ylmethyl)-amino]-1-phenyl-ethanone 

Relevant articles and documents

Base-Promoted Tandem Synthesis of 2-Azaaryl Tetrahydroquinolines

A novel method to synthesize 2-azaaryl tetrahydroquinolines by the base-promoted tandem reaction of azaaryl methyl amines and styrene derivatives is reported (over 30 examples, yields up to 95%). Mechanistic probe experiments demonstrate that the deprotonation of the benzylic C-H bond and the addition to the styrene vinyl group proceeds via the SNAr mechanism.

POTENTIAL CNS ACTIVE 1-ARYL-2-AMINO-1-ETHANOL DERIVATIVES

New N-(picolyl)-2-(methylamino)-1-aryl-1-ethanols (I) and their O-acyl derivatives (II) were synthesized.Their dopaminomimetic and antidepressant biological activities were examined and compared with the activities of N-(2-aminobenzyl)-2-(methylamino)-1-aryl-1-ethanols (III).It was established that in the reaction of N- methylamine (2) and styryl oxide, the two directions of the splitting of the epoxide ring give rise to two different products that were isolated and identified in the form of their O-acetyl derivatives (13 and 15, respectively).