698-27-1

Basic information

• Product Name: 2-HYDROXY-4-METHYLBENZALDEHYDE
• Synonyms: 4-METHYLSALICYLALDEHYDE;2-HYDROXY-4-METHYLBENZALDEHYDE;2-HYDROXY-4-METHYLBENZALDEHYDE 98+%;Benzaldehyde, 2-hydroxy-4-methyl-;2,4-Cresotaldehyde;2-hydroxy-4-methylbenzaldehyde(SALTDATA: FREE);2-Hydroxy-4-Methylbenzaldehyde, 97+%
• CAS NO: 698-27-1
• Molecular Formula: C₈H₈O₂
• Molecular Weight: 136.15
• EINECS: 211-813-7
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Alphabetical Listings;Flavors and Fragrances;G-H
• Mol File: 698-27-1.mol
• Article Data: 39

Chemical Properties

• Melting Point: 58-61 °C(lit.)
• Boiling Point: 222-223℃
• Flash Point: 88 °C
• Appearance: White/Crystalline Powder
• Density: 1.1150 (rough estimate)
• Vapor Pressure: 0.0807mmHg at 25°C
• Refractive Index: 1.5470 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform, Ethyl Acetate (Slightly)
• PKA: 8.28±0.10(Predicted)
• Water Solubility: Soluble in oil, slightly soluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-HYDROXY-4-METHYLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4-METHYLBENZALDEHYDE(698-27-1)
• EPA Substance Registry System: 2-HYDROXY-4-METHYLBENZALDEHYDE(698-27-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: PG3
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 698-27-1(Hazardous Substances Data)

Usage

Description

2-Hydroxy-4-methylbenzaldehyde is strongly odorous.

Chemical Properties

2-Hydroxy-4-methyl benzaldehyde is strong bitter-almond, phenolic odor

Occurrence

Reported found in licorice.

Uses

The intermediate for synthesis of liquid crystal. Also used as pharmaceutical intermediate.

InChI:InChI=1/C8H8O2/c1-6-2-3-7(5-9)8(10)4-6/h2-5,10H,1H3

Upstream product

• 53300-11-1 2-amino-6-methyl-cycloheptatrienone 
• 67-66-3 chloroform 
• 108-39-4 3-methyl-phenol 
• 13460-50-9 metaboric acid 
• 56-81-5 glycerol 
• 7647-01-0 hydrogenchloride 
• 7446-70-0 aluminium trichloride 
• 71-43-2 benzene 
• 89-83-8 thymol 
• 925-90-6 ethylmagnesium bromide 
• 57415-35-7 2-methoxy-4-methylbenzaldehyde 
• 100-97-0 hexamethylenetetramine 
• 104-87-0 4-methyl-benzaldehyde 
• 4885-02-3 Dichloromethyl methyl ether 

Downstream Products

• 20280-93-7 3-acetyl-7-methylcoumarin 
• 50779-65-2 6-methylbenzofuran-2-carboxylic acid 
• 89130-15-4 N,N'-bis-(2-hydroxy-4-methyl-benzyliden)-ethylenediamine 
• 99833-50-8 C₂₀H₁₉NO₃ 
• 138805-06-8 tris-(2-(2-hydroxy-4-methylbenzylideneamino)ethyl)amine 
• 1761-42-8 N-4-methylsalicylidene-o-hydroxyaniline 
• 336184-05-5 2-(3,7-dimethyloctyloxy)-4-methylbenzaldehyde 
• 148228-57-3 C₂₆H₃₀N₄O₄ 
• 853643-67-1 2-(3-methoxy-propoxy)-4-methyl-benzaldehyde 
• 1094462-02-8 (E)-2-(1,2-dichlorovinyloxy)-4-methylbenzaldehyde 
• 1131341-47-3 C₁₄H₁₆O₂ 
• 1163785-15-6 ethyl 2-(2-formyl-5-methylphenoxy)acetate 
• 1193731-83-7 (E)-N'-(2-hydroxy-4-methylbenzylidene)acetohydrazide 
• 1311992-25-2 methyl 3-(2-tert-butoxy-2-oxoethylamino)-2-(2-hydroxy-4-methylphenyl)imidazo[1,2-a]pyridine-7-carboxylate 

Relevant articles and documents

Synthesis and spectra characteristics of novel 3-(para-Bromophenyl)-7- (substituted vinyl) coumarins

Five new coumarin derivatives (5a-5e) with extending para-bromophenyl at the 3-position and substituted vinyl at the 7-position were synthesized and characterized by FT-IR, 1H NMR, and element analysis. The absorption and fluorescence character

NOVEL SIRT 1 ACTIVATOR AND MEDICINAL USE THEREOF

The present invention relates to a SIRT 1 activator and medical use thereof and in the present invention, a novel SIRT 1 activator compound based on benzo[d]furan or a benzo[d]oxazole backbone, a crystalline form thereof, a hydrate thereof, or a salt thereof was prepared, and that the compound has obesity, insulin resistance and dyslipidemia improvement effect, fatty liver improvement effect, cell aging protection, oxidative stress protection and yeast life extension effect, collagen synthesis and wrinkle improvement effect, was confirmed. Therefore, the novel SIRT 1 activator compound having the above-mentioned effect is usefully used as a pharmaceutical composition for preventing or treating metabolic diseases including obesity, diabetes, dyslipidemia, etc., or liver diseases including alcoholic or non-alcoholic fatty liver, fatty hepatitis, etc., a cosmetic composition for preventing or improving wrinkles, a health food composition for improving cell aging or extending lifespan, and the like.

Phosphine-Catalyzed [3+2] Annulation of β-Sulfonamido-Substituted Enones with Sulfamate-Derived Cyclic Imines

Phosphine-catalyzed [3+2] annulation of β-sulfonamido-substituted enones and sulfamate-derived cyclic imines has been developed, giving a series of imidazoline derivatives in moderate to excellent yields with good to excellent diastereoselectivities. A scale-up reaction worked well under mild reaction conditions. A possible mechanism was proposed on the basis of the results obtained.