69950-00-1

Basic information

• Product Name: 2-AMINO-5-THIAZOLETHIOL
• Synonyms: 2-AMINO-5-THIAZOLETHIOL;2-aMinothiazole-5-thiol
• CAS NO: 69950-00-1
• Molecular Formula: C3H4N2S2
• Molecular Weight: 132.21
• Mol File: 69950-00-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 300.2±15.0 °C(Predicted)
• Appearance: /
• Density: 1.519±0.06 g/cm3(Predicted)
• PKA: 3.00±0.50(Predicted)
• CAS DataBase Reference: 2-AMINO-5-THIAZOLETHIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-THIAZOLETHIOL(69950-00-1)
• EPA Substance Registry System: 2-AMINO-5-THIAZOLETHIOL(69950-00-1)

Safety Data

• Hazardous Substances Data: 69950-00-1(Hazardous Substances Data)

Usage

General Description

2-Amino-5-thiazolethiol is a compound with the chemical formula C3H5N3S. It is a thiol derivative of thiazole and has a molecular weight of 119.16 g/mol. This chemical is commonly used in organic synthesis and pharmaceutical research. It has potential applications in the development of drugs, as well as in the production of thiourea derivatives. Additionally, it may be used in the manufacturing of specialized chemicals and as a reagent in organic reactions. 2-Amino-5-thiazolethiol is known for its strong odor and should be handled with caution due to its potential toxicity.

Upstream product

• 23056-10-2 2-amino-5-thiocyanatothiazole 

Relevant articles and documents

Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13

Genetic depletion of cyclin-dependent kinase 12 (CDK12) or selective inhibition of an analog-sensitive CDK12 reduces DNA damage repair gene expression, but selective inhibition of endogenous CDK12 is difficult. Here, we report the development of MFH290, a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent kinome selectivity, inhibits the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II), and reduces the expression of key DNA damage repair genes. Importantly, these effects were demonstrated to be CDK12-dependent as mutation of Cys-1039 rendered the kinase refractory to MFH290 and restored Pol II CTD phosphorylation and DNA damage repair gene expression. Consistent with its effect on DNA damage repair gene expression, MFH290 augments the antiproliferative effect of the PARP inhibitor olaparib.