700381-18-6

Basic information

• Product Name: 5-FLUORO-2-METHOXYBENZYL BROMIDE 97
• Synonyms: 5-FLUORO-2-METHOXYBENZYL BROMIDE 97;5-FLUORO-2-METHOXYBENZYL BROMIDE;2-Methyloxy-5-fluorobenzyl bromide;5-Fluoro-2-methoxybenzyl bromide 97%;5-Fluoro-2-methoxybenzyl bromide, 98+%;2-(Bromomethyl)-4-fluoroanisole, 2-(Bromomethyl)-4-fluoro-1-methoxybenzene, alpha-Bromo-5-fluoro-2-methoxytoluene
• CAS NO: 700381-18-6
• Molecular Formula: C₈H₈BrFO
• Molecular Weight: 219.0509232
• Product Categories: Fluorine series
• Mol File: 700381-18-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 60-62°C
• Boiling Point: 237℃
• Flash Point: 116℃
• Appearance: /
• Density: 1.488
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Lachrymatory
• CAS DataBase Reference: 5-FLUORO-2-METHOXYBENZYL BROMIDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2-METHOXYBENZYL BROMIDE 97(700381-18-6)
• EPA Substance Registry System: 5-FLUORO-2-METHOXYBENZYL BROMIDE 97(700381-18-6)

Safety Data

• Hazard Codes: C
• RIDADR: UN3261
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 700381-18-6(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2-methoxybenzyl bromide 97 is a chemical compound with a molecular formula C8H8BrFO. It is a colorless to yellow liquid with a molecular weight of 215.053 g/mol. This chemical is commonly used as a reagent in organic synthesis and is known for its ability to introduce the 5-fluoro-2-methoxybenzyl group into various compounds. It is highly reactive and must be handled with caution due to its potential for causing irritation and harm if not used properly. Additionally, it is important to follow proper safety protocols when working with this chemical, including the use of personal protective equipment and handling it in a well-ventilated area.

InChI:InChI:1S/C8H8BrFO/c1-11-8-3-2-7(10)4-6(8)5-9/h2-4H,5H2,1H3

Upstream product

• 399-54-2 4-fluoro-2-methylanisole 
• 19415-51-1 5-fluoro-2-methoxybenzaldehyde 
• 426831-32-5 (5-fluoro-2-methoxyphenyl)methanol 

Downstream Products

• 709025-81-0 2-hydroxy-5-fluorophenyl-acetonitrile 
• 1260902-19-9 C₇H₆BrFO 
• 1292306-50-3 C₁₅H₁₂FNO 
• 501008-41-9 2-(5-fluoro-2-methoxyphenyl)acetonitrile 
• 78550-50-2 5,5'-difluoro-2,2'-dihydroxy-diphenyl-methane 
• 1539309-79-9 {(S)-1-[(S)-1-(5-fluoro-2-methoxy-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3yl carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester 
• 1403980-17-5 C₉H₆FIO 
• 1195425-74-1 (R)-2-[5-fluoro-2-(methyloxy)phenyl]-1-[(S)-4-(phenylmethyl)morpholin-2-yl]-1-(tetrahydro-2H-pyran-4-yl)ethanol 
• 948850-56-4 5-fluoro-2-methoxybenzylzinc bromide 

Relevant articles and documents

Synthesis of Phenanthridines through Palladium-Catalyzed Cascade Reaction of 2-Halo-N-Ms-arylamines with Benzyl Halides/Sulfonates

An efficient palladium-catalyzed nucleophilic substitution/C–H activation/aromatization cascade reaction between readily available 2-halo-N-Ms-arylamines (Ms = methanesulfonyl) and benzyl halides/sulfonates has been described. A wide variety of phenanthridines were synthesized in a one-pot fashion in moderate to high yields (37–86 %). Notably, this method provides a straightforward, facile approach for the synthesis of phenanthridines. The practicality was further substantiated by successfully carrying out a gram-scale preparation.

NITROGENATED FUSED RING DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE OF THE SAME FOR MEDICAL PURPOSES

[Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. [Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; RA and RB are independently halogen, cyano, alkyl, alkylsulfonyl, -OW1, -SW1, -COW2, -NW3W4, -SO2NW3W4, aryl, etc.; RC is H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, -CO-Y, -SO2-Y -S-(alkylene)-Y, -O-(alkylene)-Y, -SO2-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.

MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS

Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.