700844-17-3

Basic information

• Product Name: 7-CHLORO-2-IODOTHIENO[3,2-B]PYRIDINE-6-CARBONITRILE
• Synonyms: 7-CHLORO-2-IODOTHIENO[3,2-B]PYRIDINE-6-CARBONITRILE
• CAS NO: 700844-17-3
• Molecular Formula: C₈H₂ClIN₂S
• Molecular Weight: 320.54
• Mol File: 700844-17-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 429.985 °C at 760 mmHg
• Flash Point: 213.848 °C
• Appearance: /
• Density: 2.166 g/cm³
• CAS DataBase Reference: 7-CHLORO-2-IODOTHIENO[3,2-B]PYRIDINE-6-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-2-IODOTHIENO[3,2-B]PYRIDINE-6-CARBONITRILE(700844-17-3)
• EPA Substance Registry System: 7-CHLORO-2-IODOTHIENO[3,2-B]PYRIDINE-6-CARBONITRILE(700844-17-3)

Safety Data

• Hazardous Substances Data: 700844-17-3(Hazardous Substances Data)

Usage

General Description

7-CHLORO-2-IODOTHIENO[3,2-B]PYRIDINE-6-CARBONITRILE is a chemical compound with the molecular formula C7H2ClIN2S. It is a heterocyclic compound containing chlorine, iodine, and nitrile functional groups. 7-CHLORO-2-IODOTHIENO[3,2-B]PYRIDINE-6-CARBONITRILE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in the development of new drugs and pesticides due to its unique chemical structure. 7-CHLORO-2-IODOTHIENO[3,2-B]PYRIDINE-6-CARBONITRILE may also be used as a building block in organic synthesis for the modification of bioactive compounds and pharmaceutical ingredients. Overall, this chemical compound has diverse potential applications in the fields of medicine, agriculture, and chemical research.

Upstream product

• 700844-09-3 7-chlorothieno[3,2-b]pyridine-6-carbonitrile 
• 700844-10-6 7-chlorothieno[3,2-b]pyridine-6-carboxamide 
• 90690-94-1 7-chlorothieno<3,2-b>pyridine-6-carboxylic acid 
• 83179-01-5 ethyl 7-chlorothieno<3,2-b>pyridine-6-carboxylate 

Downstream Products

• 700844-82-2 2-iodo-7-[ (3, 4, 5-trimethoxyphenyl) amino] thieno [3,2-b] pyridine-6-carbonitrile 
• 700844-29-7 7-chloro-2-[4-(dimethylamino) phenyl] thieno [3,2-b] pyridine-6-carbonitrile 
• 700844-57-1 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-(3-formylphenyl)thieno[3,2-b]pyridine-6-carbonitrile 
• 828283-02-9 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-(2-formylphenyl)thieno[3,2-b]pyridine-6-carbonitrile 
• 700844-46-8 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-(4-formylphenyl)thieno[3,2-b]pyridine-6-carbonitrile 
• 828283-07-4 7-[(2,4-dichlorobenzyl)amino]-3-(4-formylphenyl)thieno[3,2-b]pyridine-6-carbonitrile 
• 700844-33-3 7-[(2, 4-dichloro-5-methoxyphenyl) amino]-2-phenylthieno [3,2-b] pyridine-6-carbonitrile 
• 700845-54-1 7-[(2,4-dichlorophenyl)amino]-3-(4-formylphenyl)thieno[3,2-b]pyridine-6-carbonitrile 
• 828283-06-3 7-(2,4-dichlorophenoxy)-3-(4-formylphenyl)thieno[3,2-b]pyridine-6-carbonitrile 
• 700845-55-2 7-[(2,4-dichloro-5-ethoxyphenyl)amino]-2-(4-formylphenyl)thieno[3,2-b]pyridine-6-carbonitrile 
• 855894-30-3 7-[(2,4-dichloro-5-ethoxyphenyl)amino]-2-(5-formylthien-3-yl)thieno[3,2-b]pyridine-6-carbonitrile 
• 700844-77-5 2-(4-formylphenyl)-7-[(4-phenoxyphenyl)amino]thieno[3,2-b]pyridine-6-carbonitrile 

Relevant articles and documents

NEW COMPOUNDS

There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.

Identification of 7-phenylaminothieno-[3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors

We disclose here a new class of kinase inhibitors, obtained by replacing the phenyl ring of a 3-quinolinecarbonitrile system with a thiophene ring. When suitably substituted, the resultant 7-phenylaminothieno[3,2-b]pyridine-6- carbonitrile analogues show