701-27-9

Basic information

• Product Name: 3-FLUOROBENZENESULFONYL CHLORIDE
• Synonyms: BUTTPARK 33\11-49;BENZENESULFONYL CHLORIDE, 3-FLUORO-;3-FLUOROBENZENE-1-SULFONYL CHLORIDE;3-FLUOROBENZENESULFONYL CHLORIDE;3-FLUOROBENZENESULPHONYL CHLORIDE;AKOS BB-9461;3-Fluorobenzenesulphonyl chloride 97%;3-Fluorobenzenesulphonylchloride97%
• CAS NO: 701-27-9
• Molecular Formula: C₆H₄ClFO₂S
• Molecular Weight: 194.61
• EINECS: -0
• Product Categories: Fluoro-contained benzenesulfonyl chloride series;Aromatic Halides (substituted);Benzene series;Miscellaneous;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Aryl Fluorinated Building Blocks;Building Blocks;C6;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Fluorine series
• Mol File: 701-27-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 7°C
• Boiling Point: 231-232 °C(lit.)
• Flash Point: >230 °F
• Appearance: Grey-brown to dark brown/Powder, Granules or Chunks
• Density: 1.463 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.045mmHg at 25°C
• Refractive Index: n20/D 1.529(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• BRN: 2091631
• CAS DataBase Reference: 3-FLUOROBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUOROBENZENESULFONYL CHLORIDE(701-27-9)
• EPA Substance Registry System: 3-FLUOROBENZENESULFONYL CHLORIDE(701-27-9)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-29-14-36/37/38
• Safety Statements: 26-36/37/39-45-8-30-23-27
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 701-27-9(Hazardous Substances Data)

Usage

Uses

3-Fluorobenzenesulfonyl chloride may be used in the preparation of 1-(2-bromobenzyl)-2-(3-fluorophenyl)pyrrole and 1-(2-bromobenzyl)-2,5-bis(3-fluorophenyl)pyrrole.

General Description

3-Fluorobenzenesulfonyl chloride, also known as m-fluorobenzenesulfonyl chloride, is a fluorinated arylsulfonyl chloride. It can be prepared from 1,3-benzenedisulfonyl fluoride.

InChI:InChI=1/C6H4ClFO2S/c7-11(9,10)6-3-1-2-5(8)4-6/h1-4H

Upstream product

• 372-19-0 meta-fluoroaniline 
• 768-35-4 3-fluorophenylboronic acid 
• 625-98-9 3-chlorofluorobenzene 
• 128254-27-3 2-Fluoro-1,4-bis-trimethylsilanyl-benzene 
• 2557-77-9 3-fluorothiophenol 
• 7217-41-6 (3-fluorophenyl)trimethylsilane 

Downstream Products

• 111711-78-5 5-Ethoxy-1-(3-fluoro-benzenesulfonyl)-pyrrolidin-2-one 
• 878376-15-9 tert-butyl [5-({[(3-fluorophenyl)sulfonyl]amino}methyl)-1,3-thiazol-2-yl]carbamate 
• 681246-46-8 benzyl 3-bromo-6-{1[(3-fluorophenyl)sulfonyl]amino}-2-methylbenzoate 
• 875151-77-2 (S)-1-(3-(fluoro)benzenesulfonyl)-piperidine-2-carboxylic acid benzyl ester 
• 875151-95-4 (S)-2-{[(S)-1-(3-fluoro-benzenesulfonyl)-piperidine-2-carbonyl]-amino}-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester 
• 767624-61-3 3-fluoro-N-[2-amino-4-(4-methyl-1-piperazinyl)-phenyl]benzenesulfonamide 
• 478615-49-5 3-Fluoro-N-[4-(4-methyl-1,4-diazepan-1-yl)-1-naphthyl]benzenesulfonamide, Hydrochloride 
• 898568-30-4 N-(1-Benzyl-2-oxo-6-phenyl-1,2,3,4-tetrahydro-1,5-naphthyridin-3-yl)-3-fluorobenzenesulfonamide 
• 881427-41-4 {5-[(3-fluorobenzenesulfonyl)-(4-fluorobenzyl)amino]-2-propylbenzoimidazol-1-yl}acetic acid tert-butyl ester 
• 942137-51-1 3-fluoro-N-(5-fluoro-3-methoxypyrazin-2-yl)-benzenesulfonamide 

Relevant articles and documents

Oxyhalogenation of thiols and disulfides into sulfonyl chlorides/bromides using oxone-KX (X = Cl or Br) in water

A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides by oxyhalogenation of thiols and disulfides with oxone-KX (X = Cl or Br) using water as the solvent is described. This journal is the Partner Organisations 2014.

Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.

Elimination of substituted fluoren-9-ylmethyl benzenesulfonates: Hammett substituent effects at a mechanistic borderline

Rates of elimination of fourteen substituted fluoren-9-ylmethyl benzenesulfonates have been measured in methanolic sodium methoxide and 90% aqueous ethanolic solutions of triethylamine, trimethylamine and 4-methyl morpholine. For the sodium methoxide, a linear Hammett plot with ρ = 0.74, consistent with reaction by an E2 mechanism, is observed. For the amine bases the Hammett plots are curved, suggesting a transition from an E2 mechanism for electron-withdrawing substituents to an irreversible E1cB mechanism with a smaller value of ρ for electron-donating substituents. The evidence for a change of mechanism is weakened by systematic and random deviations of substituents from correlations which span small changes in reactivity (less than ten-fold), by a surprisingly large value of ρ = 2 implied for the concerted (E2) reaction and by the possible influence of negative hyperconjugation. Nevertheless, it is consistent with independent evidence that the borderline between concerted and stepwise mechanisms is associated with chemically distinguishable reaction paths, even though pronounced carbanion character (and probably a small extent of bond-breaking to the leaving group) ensures a degree of similarity of structure and sensitivity to substituents of their transition states.