70110-39-3

Basic information

• Product Name: p-Phenylene-bis-1,1-(3-benzoyl-2-thiourea)
• CAS NO: 70110-39-3
• Molecular Formula: C₂₂H₁₈N₄O₂S₂
• Molecular Weight: 434.543
• Mol File: 70110-39-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: p-Phenylene-bis-1,1-(3-benzoyl-2-thiourea)(CAS DataBase Reference)
• NIST Chemistry Reference: p-Phenylene-bis-1,1-(3-benzoyl-2-thiourea)(70110-39-3)
• EPA Substance Registry System: p-Phenylene-bis-1,1-(3-benzoyl-2-thiourea)(70110-39-3)

Safety Data

• Hazardous Substances Data: 70110-39-3(Hazardous Substances Data)

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 98-88-4 benzoyl chloride 
• 106-50-3 1,4-phenylenediamine 
• 532-55-8 Benzoyl isothiocyanate 

Downstream Products

• 1519-70-6 N,N'-bis(thiocarbamoyl)-1,4-phenylenediamine 

Relevant articles and documents

Fe3O4@SiO2 nanoparticle supported ionic liquid for green synthesis of antibacterially active 1-carbamoyl-1-phenylureas in water

In the present work, we have designed a novel, heterogeneous and recyclable magnetic Br?nsted acidic ionic liquid based on 5-phenyl-1H-tetrazole. The {Fe3O4@SiO2@CH2)35-phenyl-1H-tetrazole-SO3H/Cl} ([FSTet-SO3H]Cl) was prepared via the immobilization of 5-phenyl-1H-tetrazole-bonded sulfonic acid onto the surface of silica-coated magnetic nanoparticles using 3-chloropropyltriethoxysilane as a linker. The catalyst was characterized by XRD, TEM, FESEM, EDS, TG-DTA, and FT-IR. The ability and high activity of this catalyst were demonstrated in the synthesis of 1-carbamoyl-1-phenylureas with good to excellent yields via a new, simple and one-pot procedure in aqueous media under reflux conditions. This procedure has advantages such as high yields, short reaction times, a simple methodology and work-up process, green reaction conditions, high stability, catalytic activity, and easy preparation, separation and reusability of the catalyst. The synthesis of these compounds was confirmed by FT-IR, 1H NMR, 13C NMR and CHN. In addition, we investigated the biological properties of the 1-carbamoyl-1-phenylureas as newly synthesized compounds. The described catalyst could be easily separated from the reaction mixture by additional magnetic force and reused several times without a remarkable loss of its catalytic activity and any considerable changes in the product yield and the reaction time.

An efficient, facial and green synthesis of substituted thiourea

A series of novel substituted N,N'-di(arylaminothiocarbonyl)terephthalamide and 1,4-di(aryloylthioureido)benzene were synthesized by the reaction of terephthaloyl dichloride, ammonium thiocyanate and primary amines, 1,4-phenylenediamine and acyl halide derivatives. The reaction has been completed within 0.5 h in solvent-free condition by grinding the mixture of reactants and afforded the substituted thiourea in good yields.

Synthesis and spectroscopic properties of some new N,N'-disubstituted thioureas of potential biological interest

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