70232-19-8 Usage
Description
(S)-2-((TERT-BUTOXYCARBONYL)AMINO)-4-(DIMETHYLAMINO)-4-OXOBUTANOIC ACID is a chemical compound derived from the amino acid glutamic acid. It is characterized by the presence of a tert-butoxycarbonyl (Boc) group, which serves as a protecting group for amines, and a dimethylamino group. (S)-2-((TERT-BUTOXYCARBONYL)AMINO)-4-(DIMETHYLAMINO)-4-OXOBUTANOIC ACID is known for its role as a coupling reagent in peptide synthesis and its utility in organic chemistry for selective functional group manipulation.
Uses
Used in Pharmaceutical Industry:
(S)-2-((TERT-BUTOXYCARBONYL)AMINO)-4-(DIMETHYLAMINO)-4-OXOBUTANOIC ACID is used as a coupling reagent in peptide synthesis for the production of peptides and small molecule drugs. Its ability to facilitate the formation of peptide bonds is crucial for creating complex peptide structures with potential therapeutic applications.
Used in Organic Chemistry:
In the field of organic chemistry, (S)-2-((TERT-BUTOXYCARBONYL)AMINO)-4-(DIMETHYLAMINO)-4-OXOBUTANOIC ACID is utilized as a protecting group for the amine group. This function allows chemists to selectively manipulate other functional groups within a molecule without affecting the amine, which is particularly valuable in the synthesis of complex organic compounds and the development of new chemical reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 70232-19-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,2,3 and 2 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 70232-19:
(7*7)+(6*0)+(5*2)+(4*3)+(3*2)+(2*1)+(1*9)=88
88 % 10 = 8
So 70232-19-8 is a valid CAS Registry Number.
70232-19-8Relevant articles and documents
Active-site studies of neurohypophyseal hormones: Synthesis and pharmacological properties of [5-(N4,N4-dimethylasparagine)]oxytocin
Walter,Stahl,Caplaneris,Cordopatis,Theodoropoulos
, p. 890 - 893 (1979)
Synthesis and biological properties of [5 (N4, N4-demethylasparagine)] oxytocin are reported. In this analogue, the hydrogens of the primary carboxamide moiety in the side chain of the asparagine residue in position 5 of the posterior pituitary hormone oxytocin have been replaced by two methyl groups. The protected nonapeptide intermediate was prepared by a stepwise procedure using solution techniques. The analogue possess 4.60 ± 0.03 units/mg (mean ± SEM) uterotonic activity on the isolated rat uterine horn and 9.14 ± 0.03 units/mg of avian vasodepressor activity. Moreover, it displays an identical intrinsic activity in the in vitro rat uterotonic assay as oxytocin, when tested in the presence of either 0.5 mM Ca2+ (standard assay conditions) or at reduced levels of Ca2+ (0.3, 0.15, and 0.05 mM). This result is significant in view of the proposed biologically active model of oxytocin, in which the side chain of the 5 position residue was assigned to contain an 'active element' responsible for the intrinsic activity of the hormone when bound to the uterine receptor.
