70258-18-3

Basic information

• Product Name: 2-Chloro-5-chloromethylpyridine
• Synonyms: 2-CHLORO-5-CHLOROMETHYLPYRIDINE 90%;2-Chloro-5-ChloroMethylPyridine(Ccmp)98%;2-Chloro-5-Chloro Methyl Pyridine (Ccmp) 98%;Pyridine, 2-chloro-5-(chloromethyl)- (9CI);2-Chloro-5-chloromethylpyridine, tech., 90%;imidacloprid impurity;2-CHLORO-5-(CHLOROMETHYL)PYRIDINE[FOR IMIDACLOPRID];2-CHLORO-5-CHLOROMETHYLPYRIDINE 2-CHLORO-5-CHLOROMETHYLPYRIDINE
• CAS NO: 70258-18-3
• Molecular Formula: C₆H₅Cl₂N
• Molecular Weight: 162.02
• EINECS: -0
• Product Categories: HALOMETYL;Pyridine;Pyridine series;Methyl Halides;Pyridines;Chloropyridines;Halopyridines;Methyl Halides;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;API Intermediate;Heterocycle-Pyridine series;Pharmaceutical intermediates
• Mol File: 70258-18-3.mol
• Article Data: 35

Chemical Properties

• Melting Point: 37-42 °C(lit.)
• Boiling Point: 267.08°C (rough estimate)
• Flash Point: >230 °F
• Appearance: Beige/Moist Crystals
• Density: 1.4411 (rough estimate)
• Vapor Pressure: 0.177mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Refrigerator
• PKA: -0.75±0.10(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 1635690
• CAS DataBase Reference: 2-Chloro-5-chloromethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-chloromethylpyridine(70258-18-3)
• EPA Substance Registry System: 2-Chloro-5-chloromethylpyridine(70258-18-3)

Safety Data

• Hazard Codes: C,Xi,F
• Statements: 22-34-36-10
• Safety Statements: 26-36/37/39-45-25-36-16
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: LACHRYMATOR, CORROSIVE
• PackingGroup: II
• Hazardous Substances Data: 70258-18-3(Hazardous Substances Data)

Usage

Description

2-Chloro-5-chloromethylpyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds1, having insecticidal activity. It is the raw material of pesticide products such as imidacloprid, acetamiprid as well as bactericide and herbicide2,3.

Sources

https://www.alfa.com/en/catalog/L19284/ https://www.trc-canada.com/product-detail/?C364715 www.szqhbio.com/wap_news_detailen/id/1.htm

Chemical Properties

beige moist crystals

Uses

2-Chloro-5-(chloromethyl)pyridine is used for the synthesis of various pharmaceutical compounds. It can also be used for the synthesis of new neonicotinoid compounds.

InChI:InChI=1/C6H5Cl2N/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3

Synthetic route

2,-chloro-2-(chloromethyl)-4-cyanobutyraldehyde (150807-86-6) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With phosgene In toluene at 50℃; for 6h; Temperature;	97%
In chlorobenzene at 105 - 110℃; for 0.283333h; Temperature;	79.5%

5-(hydroxymethyl)pyridin-2-ol (109205-68-7) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With phosphorus pentachloride In chloroform; water; trichlorophosphate	95%

2-chloro-5-methylpyridine (18368-64-4) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With chlorine at 115 - 120℃; for 5.5h; Temperature;	93.5%
With chlorine at 120℃; under 3750.38 Torr; Temperature; Pressure; Green chemistry;	93.2%
With 2,2'-azobis(isobutyronitrile); chlorine In dichloromethane at 120℃; under 7500.75 - 15001.5 Torr; for 1h;	70%

2‑chloro‑2-chloromethyl-4-cyanobutyraldehyde → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With phosgene In N,N-dimethyl-formamide; toluene at 20 - 30℃; for 4h; Temperature;	91.2%

2-chloro-5-(Trichloromethyl)-pyridine (69045-78-9) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With ammonium hydroxide; 5%-palladium/activated carbon; hydrogen In acetic acid methyl ester; water at 55 - 60℃; under 6000.6 Torr; for 7h; Reagent/catalyst; Pressure; Solvent; Temperature; Autoclave;	88.6%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + 2,-chloro-2-(chloromethyl)-4-cyanobutyraldehyde (150807-86-6) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With N,N-dimethyl-formamide In toluene at 90 - 100℃; for 2.5h; Concentration; Temperature; Solvent; Reagent/catalyst;	85.8%

C11H13ClOS + tert.-butyl lithium (594-19-4) + 2-chloro-5-(4,4, 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (444120-94-9) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3) + C15H21BClNO2 + 1-Methyl-4-((R)-2-methyl-propane-2-sulfinyl)-benzene (1693-83-0)

Conditions	Yield
With zinc(II) chloride In tetrahydrofuran; toluene; pentane at -78 - 20℃; for 22h; Inert atmosphere;	A 25% B 8% C 69%

3-Methylpyridine (108-99-6) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With chlorine at 250 - 282℃; for 0.25h; Reagent/catalyst; Inert atmosphere;	51%
Multi-step reaction with 3 steps 1: sodium amide / ethanol / 2.17 h / 66 °C / Reflux 2: methyl nitrite; hydrogenchloride / methanol / 5 h / 10 - 12 °C 3: methyl nitrite; hydrogenchloride / methanol / 5 h / 10 - 12 °C View Scheme

2-Chloro-5-hydroxymethylpyridine (21543-49-7) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With thionyl chloride In dichloromethane for 3h;
With thionyl chloride In chloroform
With pyridine; thionyl chloride

6-Chloronicotinic acid methyl ester (73781-91-6) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: DIBAL-H / tetrahydrofuran; hexane / 1 h / 0 °C 2: SOCl2 / CH2Cl2 / 3 h View Scheme
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C 2: thionyl chloride / dichloromethane / 2 h View Scheme
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 2: thionyl chloride / dichloromethane / 2 h / Inert atmosphere View Scheme

2-chloro-5-chloromethylpyridine chydrochloride (82674-16-6) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane; water

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With phosphorus pentachloride; trichlorophosphate
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Reflux 2: thionyl chloride / dichloromethane / 1 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Reflux 2: thionyl chloride / dichloromethane / 1 h / 20 °C / Reflux View Scheme

2,-chloro-2-(chloromethyl)-4-cyanobutyraldehyde (150807-86-6) + phosphorus pentachloride (10026-13-8, 874483-75-7) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With sodium hydrogencarbonate In hydrogenchloride; N,N-dimethyl-formamide

4-chloro-4-chloromethyl-5-oxopentamide (150807-87-7) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
In N,N-dimethyl-formamide

oxalyl dichloride (79-37-8) + 2-chloro-5-acetaminomethylpyridine (175424-74-5) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
In N-methyl-acetamide; acetonitrile

(6-methoxypyridin-3-yl)methanol (58584-63-7) + N,N-dibutylformamide (761-65-9) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With nitrogen; sodium carbonate In water; toluene

5-(hydroxymethyl)-1,2-dihydropyridin-2-one (109205-68-7) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With phosphorus pentachloride; sodium carbonate; trichlorophosphate In ethyl acetate

2-methoxy-5-bis-(methoxy)methyl-pyridine (133735-66-7) + phosphorus pentachloride (10026-13-8, 874483-75-7) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With sodium hydroxide; trichlorophosphate

2-Chloro-5-hydroxymethylpyridine (21543-49-7) + 1,2-dichloro-ethane (107-06-2) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
With thionyl chloride; sodium bicarbonate In chloroform; water

2-((6-chloropyridin-3-yl)oxy)acetic acid (234109-28-5) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 16 h / 20 °C / Inert atmosphere 2: triphenylphosphine; tetrachloromethane / acetonitrile / 12 h / 20 °C / Inert atmosphere View Scheme

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 2-chloro-5-(chloromethyl)pyridine (70258-18-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: methyl nitrite; hydrogenchloride / methanol / 5 h / 10 - 12 °C 2: methyl nitrite; hydrogenchloride / methanol / 5 h / 10 - 12 °C View Scheme

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + ethylenediamine (107-15-3) → N'-((6-chloropyridin-3-yl)methyl)ethane-1,2-diamine (101990-44-7)

Conditions	Yield
	100%
	100%
With sodium hydroxide In acetonitrile at 20℃; for 24h;	99%

pyrrolidine (123-75-1) + 2-chloro-5-(chloromethyl)pyridine (70258-18-3) → 2-chloro-5-(pyrrolidin-1-ylmethyl)pyridine (230617-66-0)

Conditions	Yield
With potassium carbonate In acetonitrile for 3.5h; Reflux;	100%
With potassium carbonate In acetonitrile Heating;	96%

3-(4-t-butylphenyl)-N-2,2-trimethylpropylamine + 2-chloro-5-(chloromethyl)pyridine (70258-18-3) → N-[3-(4-t-butylphenyl)-2,2-dimethylpropyl]-6-chloro-N-methyl-3-pyridylmethylamine (374075-54-4)

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 50℃; for 8h;	100%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + (S)-2-methyl-1-((2-nitrophenyl)sulfonyl)piperazine → (S)-4-((6-chloropyridin-3-yl)methyl)-2-methyl-1-((2-nitrophenyl)sulfonyl)piperazine

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 60℃; for 5.5h; Inert atmosphere;	100%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + cis-13-1,4,7,10-tetraazatetracyclo<5.5.2.04,14010,13>tetradecane (74199-09-0, 79236-92-3) → 2a,6a-bis[(6-chloropyridin-3-yl)methyl]decahydro-4a,8a-dizaz-2a,6a-diazoniacyclopenta[fg]acenaphthene diiodide

Conditions	Yield
With sodium iodide In acetonitrile at 92℃; for 20 - 60h;	99%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + methylamine (74-89-5) → 1-(6-chloropyridin-3-yl)-N-methylmethanamine (120739-62-0)

Conditions	Yield
Stage #1: methylamine In toluene at -5 - 5℃; Large scale; Stage #2: 2-chloro-5-(chloromethyl)pyridine In toluene at -5 - 2℃; Large scale;	98.5%
In water at 62℃; under 1650.17 Torr; for 1h; Temperature; Pressure;	97.7%
In water at 60℃; for 6h;	95.6%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + Kryptofix 21 (31249-95-3) → 7,13-bis[(6-chloropyridin-3-yl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile Reflux;	98%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (23978-55-4) → 7,16-bis[(6-chloropyridin-3-yl)methyl]-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile Reflux;	98%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + N-(2,2-difluoroethyl)prop-2-en-1-amine (1178819-40-3) → N-[(6-chloropyridin-3-yl)methyl]-N-(2,2-difluoroethyl)prop-2-en-1-amine (1375635-65-6)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine at 70℃; for 16h;	97.9%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + 2-cyanomethylidene-1,3-thiazolidine → thiacloprid

Conditions	Yield
With N,N,N',N'-tetramethylguanidine In dichloromethane at 10 - 45℃; for 15h; Temperature; Solvent; Reagent/catalyst; Large scale; Green chemistry;	97.6%

2-thiazolylamine (96-50-4) + 2-chloro-5-(chloromethyl)pyridine (70258-18-3) → 3-(6-chloro-pyridin-3-ylmethyl)-3H-thiazol-2-ylideneamine (147670-59-5)

Conditions	Yield
In isopropyl alcohol for 40h; Heating;	97%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + dimethyl amine (124-40-3) → N,N-dimethyl-6-chloro-nicotinamide (54864-83-4)

Conditions	Yield
In tetrahydrofuran; dichloromethane at 0 - 20℃;	97%

(S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐ol (187235-08-1) + 2-chloro-5-(chloromethyl)pyridine (70258-18-3) → (6S)-6-[(6-chloro-3-pyridinyl)methoxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (1257426-57-5)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 5 - 20℃;	97%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 5 - 20℃; for 16h;	97%
With sodium hydride In N,N-dimethyl-formamide at 5 - 20℃;

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + sodium cyanide (143-33-9) → (6-chloro-pyridin-3-yl)-acetonitrile (39891-09-3)

Conditions	Yield
In ethanol; water at 0 - 100℃; for 20h;	96%
With potassium iodide In ethanol; water at 85℃; for 5h;	45.6%
In ethanol; water for 10h; Heating;

2-chloro-5-(chloromethyl)pyridine (70258-18-3) → 5-(azidomethyl)-2-chloro-pyridine

Conditions	Yield
With sodium azide In ethanol for 6h; Reflux;	95%
With sodium azide In ethanol Reflux;	95%
With sodium azide In ethanol Heating;
With sodium azide In ethanol Reflux;
With sodium azide In ethanol Reflux;

N-methylcyclohexylamine (100-60-7) + 2-chloro-5-(chloromethyl)pyridine (70258-18-3) → (6-chloro-pyridin-3-ylmethyl)-cyclohexyl-methyl-amine (764715-44-8)

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; for 20h;	95%

tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride (1023301-84-9) + 2-chloro-5-(chloromethyl)pyridine (70258-18-3) → tert-butyl 2-((6-chloropyridin-3-yl)methyl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

Conditions	Yield
With potassium carbonate In acetonitrile at 70℃; for 16h;	95%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + tert-butyl (1R,5S)-3,8-diazabicyclo[3.2.1]octane-3-carboxylate (201162-53-0) → tert-butyl 8-[(6-chloropyridin-3-yl)methyl]-3,8-diazabicyclo[3.2.1]octane-3-carboxylate

Conditions	Yield
With potassium carbonate In acetonitrile at 70℃; for 16h;	95%

2-aminopyridine (504-29-0) + 2-chloro-5-(chloromethyl)pyridine (70258-18-3) + ethyl trifluoroacetate, (383-63-1) → N-[1-[(6-chloro-3-pyridinyl)methyl]-2(1H)-pyridinylidene]-2,2,2-trifluoro-acetamide (1363400-41-2)

Conditions	Yield
Stage #1: 2-aminopyridine; ethyl trifluoroacetate, With sodium methylate In methanol; N,N-dimethyl-formamide at 20 - 25℃; for 1h; Stage #2: 2-chloro-5-(chloromethyl)pyridine In N,N-dimethyl-formamide at 60℃; for 3.25h; Temperature; Solvent; Reagent/catalyst;	94.7%
Stage #1: 2-aminopyridine; ethyl trifluoroacetate, In N,N-dimethyl-formamide; toluene at 60 - 65℃; for 8h; Stage #2: 2-chloro-5-(chloromethyl)pyridine With potassium carbonate In N,N-dimethyl-formamide; toluene at 60 - 65℃; for 15h; Solvent;	81.2%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + sodium thiomethoxide (5188-07-8) → 2-chloro-5-[(methylthio)methyl]-pyridine (1021870-94-9)

Conditions	Yield
In ethanol	94%
In ethanol at 20℃;	94%
In methanol at 50℃; for 20h; Solvent; Temperature;

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + potassium ethyl xanthogenate (140-89-6) → S-[(6-chloropyridin-3-yl)methyl] O-ethyl carbonodithioate (1092444-77-3)

Conditions	Yield
In acetone Inert atmosphere;	94%
In acetone at 23℃; for 16h; Inert atmosphere; stereoselective reaction;	94%

4-ethylpiperazine (5308-25-8) + 2-chloro-5-(chloromethyl)pyridine (70258-18-3) → 5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine (1180132-17-5)

Conditions	Yield
at 60 - 70℃; for 2h; Time; Green chemistry;	94%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + potassium phtalimide (1074-82-4) → ((2-chloro-5-pyridinyl)methyl)isoindol-1,3-dione (120739-60-8)

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 5h;	93.3%
In N,N-dimethyl-formamide at 20℃;	19.5 g

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + 5-(ethoxycarbonyl)-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-thione (113697-57-7) → ethyl 1-[1-(6-chloropyridin-3-yl-methyl)-2-(6-chloropyridin-3-yl-methylthio)-6-(4-methoxyphenyl)-4-methyl-1,6-dihydropyrimidin-5-yl]carboxylate (1313193-59-7)

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	93%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + nitroguanidine (556-88-7) + ethylenediamine (107-15-3) → 1-(6-chloronicotinyl)-2-nitroiminoimidazoline (105827-78-9)

Conditions	Yield
With hydrogenchloride In ethanol; water at 50℃; for 3h; pH=4 - 5; Reagent/catalyst; Temperature; pH-value; Ionic liquid;	93%

2-chloro-5-(chloromethyl)pyridine (70258-18-3) + methyl N-cyanoacetimidate (5652-84-6) + methylamine (74-89-5) → acetamiprid

Conditions	Yield
Stage #1: 2-chloro-5-(chloromethyl)pyridine; methylamine In toluene at 3 - 25℃; for 6h; Large scale; Stage #2: methyl N-cyanoacetimidate With ethanol In toluene at 35℃; for 4h; Temperature; Large scale;	93%

potassium cyanide + 2-chloro-5-(chloromethyl)pyridine (70258-18-3) → (6-chloro-pyridin-3-yl)-acetonitrile (39891-09-3)

Conditions	Yield
In ethanol; water at 50℃; for 20h;	92%

Upstream product

• 150807-86-6 2,-chloro-2-(chloromethyl)-4-cyanobutyraldehyde 
• 10026-13-8 phosphorus pentachloride 
• 79-37-8 oxalyl dichloride 
• 175424-74-5 2-chloro-5-acetaminomethylpyridine 
• 133735-66-7 2-methoxy-5-bis-(methoxy)methyl-pyridine 
• 18368-64-4 2-chloro-5-methylpyridine 
• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 
• 21543-49-7 2-Chloro-5-hydroxymethylpyridine 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 108-99-6 3-Methylpyridine 
• 234109-28-5 2-((6-chloropyridin-3-yl)oxy)acetic acid 
• 594-19-4 tert.-butyl lithium 
• 444120-94-9 2-chloro-5-(4,4, 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 

Downstream Products

• 105827-78-9 1-(6-chloronicotinyl)-2-nitroiminoimidazoline 
• 101990-44-7 N'-((6-chloropyridin-3-yl)methyl)ethane-1,2-diamine 
• 543697-50-3 3-{2-[(2R,3R,4S,5R,6R)-6-(5-Azido-pentyloxymethyl)-3,4-bis-benzyloxy-5-(6-chloro-pyridin-3-ylmethoxy)-tetrahydro-pyran-2-yloxy]-ethyl}-1-benzenesulfonyl-1H-indole 
• 39891-09-3 (6-chloro-pyridin-3-yl)-acetonitrile 
• 924669-64-7 2-((6-chloropyridin-3-yl)methylamino)cyclopentanecarbonitrile 
• 764715-23-3 (R)-1-(6-chloro-pyridin-3-ylmethyl)-pyrrolidin-3-ol 
• 1263285-58-0 C₁₇H₁₈ClNO₃ 
• 120739-60-8 ((2-chloro-5-pyridinyl)methyl)isoindol-1,3-dione 
• 214419-64-4 2-chloro-5-(3-fluoro-4-nitro-phenoxymethyl)-pyridine 
• 120739-62-0 1-(6-chloropyridin-3-yl)-N-methylmethanamine 
• 55676-22-7 3-acetyl-6-chloropyridine 
• 1126093-36-4 (E)-2-chloro-5-cinnamylpyridine 

Relevant articles and documents

1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors

N6-methyladenosine (m6A) is the most frequent of the 160 RNA modifications reported so far. Accumulating evidence suggests that the METTL3/METTL14 protein complex, part of the m6A regulation machinery, is a key player in a variety of diseases including several types of cancer, type 2 diabetes, and viral infections. Here we report on a protein crystallography-based medicinal chemistry optimization of a METTL3 hit compound that has resulted in a 1400-fold potency improvement (IC50 of 5 nM for the lead compound 22 (UZH2) in a time-resolved F?rster resonance energy transfer (TR-FRET) assay). The series has favorable ADME properties as physicochemical characteristics were taken into account during hit optimization. UZH2 shows target engagement in cells and is able to reduce the m6A/A level of polyadenylated RNA in MOLM-13 (acute myeloid leukemia) and PC-3 (prostate cancer) cell lines.

Method for preparing chloromethylpyridine 2- chloride -5. (by machine translation)

The mass percentage of, the precious metal in 2 - the precious metal catalyst of the noble metal 2 - catalyst of the " invention is that the mass percentage of 1%-10%; the noble 2 - metal 2 - in the precious metal; catalyst, 2 - containing the active, carbon or, aluminum oxide as the carrier is, the mass percent of the noble metal catalyst in the precious metal catalyst with the active carbon or alumina as the carrier 0.1%-0.5%; 2 - 2 - 82%, 98%, ". (by machine translation)

Method for continuously preparing 2-chloro-5-chloromethylpyridine by microchannel reactor

The invention discloses a method for continuously preparing 2-chloro-5-chloromethylpyridine by a microchannel reactor. The method includes the following steps: simultaneously injecting 2-chloro-5-methylpyridine and chlorine as raw materials into the microchannel reactor for chlorination, collecting a reaction product after the reaction, and crystallizing and distilling the reaction product to obtain the 2-chloro-5-chloromethylpyridine. The method has the advantages that the microchannel reactor is applied to carry out the reaction, the mixing uniformity is high, and the reaction time is greatly shortened; the inner diameter of a microchannel is small while the specific surface area thereof is large, reaction materials are instantaneously mixed uniformly in a precise ratio, the raw materialutilization rate and the product quality are improved, and the selectivity of the product is high, so that the productivity and purity of the product are improved while the production cost is lowered; in addition, the use of organic solvents is avoided in the preparation process, no waste polluting the environment is discharged in the production process, and environmental pollution and harm to the human body are reduced.