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7026-49-5

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7026-49-5 Usage

Molecular weight

284.32 g/mol

Chemical structure

1H-Imidazole-4-carboxamide, 5-amno-N,1-bis(phenylmethyl)-

Physical state

Solid

Appearance

White or off-white crystalline solid

Solubility

Slightly soluble in water, soluble in organic solvents such as ethanol and methanol

Melting point

192-196°C

Biological activity

Free radical scavenger, antioxidant, potential therapeutic benefits in neurodegenerative diseases and inflammation, protective against oxidative stress and damage, prevents lipid peroxidation and maintains cell membrane integrity.

Check Digit Verification of cas no

The CAS Registry Mumber 7026-49-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,2 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 7026-49:
(6*7)+(5*0)+(4*2)+(3*6)+(2*4)+(1*9)=85
85 % 10 = 5
So 7026-49-5 is a valid CAS Registry Number.

7026-49-5Downstream Products

7026-49-5Relevant articles and documents

THE CHEMICAL SIMULATION OF THE "ATP-IMIDAZOLE" CYCLE

Ranganathan, Darshan,Farooqui, Firdous,Bhattacharyya, Diphti,Mehrotra, Sanjiv,Kesavan, K.

, p. 4481 - 4492 (2007/10/02)

The synthetic strategy inherent in the "ATP-Imidazole" cycle and centred around the vicinal disposition of -NH2 and -CONH2 functions, has been demonstrated with anthranilamide (2) and 1-benzyl-5-aminoimidazole-4-carboxamide (1) as regeneratable carriers involving specifically N-alkylated quinazolin-4-ones, hypoxantines and adenines, as key intermediates.The isolation and characterization of the enamine (22) coupled with other observations has made it possible to rationalize the pathways involved in these cyclic operations.The practical utility of the synthetic strategy using regeneratable carriers has beem illustrated with the synthesis of a range of 1,5-disubstituted imidazoles.Whilst pathways leading to specific N-alkylation in the Natural cycle and in simulation studies are comparable, the subsequent events take place in a reverse order, primarily because of the divergence in the hydrolitic profile of the alkylated substrates.The action of dilute alkali on 3-alkylated quinazolin-4-ones leads to 2-3 rather than 3-4 bond rupture.Endeavours to promote the latter path, by blocking the 2 position gave unexpected results. 2-Methyl-3-phenacyl quinazolin-4-one gave with dilute alkali the novel aromatic tricyclic system (32) from trans-annular cyclization.On the other hand the 2-blocked 3-benzamido quinazolin-4-ones (33) and (34) gave triazoles (35) and (36) arising from the desired 3-4 rupture followed by cyclization initiated by the resulting amidine unit. 2-Phenil-3-benzamidoquinazolin-4-one (34) with distilled water at 200 deg C gave a number of products whicc have been identified and their formation explained.

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