7038-63-3

Basic information

• Product Name: (4,6-DICHLORO-PYRIMIDIN-2-YL)-DIETHYLAMINE
• Synonyms: (4,6-DICHLORO-PYRIMIDIN-2-YL)-DIETHYLAMINE;4,6-dichloro-N,N-diethylpyriMidin-2-aMine
• CAS NO: 7038-63-3
• Molecular Formula: C8H11Cl2N3
• Molecular Weight: 495.5771
• Mol File: 7038-63-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 670.7 °C at 760 mmHg
• Flash Point: 359.4 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 7.49E-18mmHg at 25°C
• Refractive Index: 1.69
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (4,6-DICHLORO-PYRIMIDIN-2-YL)-DIETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (4,6-DICHLORO-PYRIMIDIN-2-YL)-DIETHYLAMINE(7038-63-3)
• EPA Substance Registry System: (4,6-DICHLORO-PYRIMIDIN-2-YL)-DIETHYLAMINE(7038-63-3)

Safety Data

• Hazardous Substances Data: 7038-63-3(Hazardous Substances Data)

Usage

General Description

(4,6-Dichloro-pyrimidin-2-yl)-diethylamine is a chemical compound that is commonly used as a reagent in organic and pharmaceutical synthesis. It is a clear, colorless liquid with a strong odor and is highly reactive. (4,6-DICHLORO-PYRIMIDIN-2-YL)-DIETHYLAMINE is known for its strong nucleophilic properties, making it useful in the formation of various organic compounds. It is also used in the synthesis of drug intermediates and agrochemicals. Additionally, it is important to handle this compound with caution as it may be harmful if ingested or inhaled, and may cause skin and eye irritation.

InChI:InChI=1/C31H25N7/c1-22-16-18-25(19-17-22)33-31(30-34-27-14-8-9-15-28(27)35-30)36-32-20-24-21-38(26-12-6-3-7-13-26)37-29(24)23-10-4-2-5-11-23/h2-21,33,36H,1H3

Upstream product

• 3764-01-0 2,4,6-trichloropyrimidine 
• 109-89-7 diethylamine 
• 4489-34-3 4,6-dichloro-2-(methylsulfonyl)pyrimidine 

Relevant articles and documents

Chemoselective reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and related electrophiles with amines

Chemoselective SNAr reactions of 4,6-dichloro-2-(methylsulfonyl) pyrimidine and several related electrophiles with amines and their derivatives are described. In the presence of weak bases anilines and secondary aliphatic amines selectively displace the chloride group. Deprotonated anilines and their carbonyl derivatives displace the sulfone group. Sterically and electronically unbiased primary aliphatic amines selectively displace the sulfone group in 4,6-dichloro-2-(methylsulfonyl)pyrimidine; however, their reactions with other electrophiles generally are less selective. Steric-driven selectivity explanation was proposed. Georg Thieme Verlag Stuttgart. New York.

HETEROARYL COMPOUNDS

This invention relates to compounds of formula (I) their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.