704-97-2

Basic information

• Product Name: 3-(2-fluorophenyl)prop-2-ynoic acid
• Synonyms: 2-propynoic acid, 3-(2-fluorophenyl)-; 3-(2-Fluorophenyl)propiolic acid
• CAS NO: 704-97-2
• Molecular Formula: C₉H₅FO₂
• Molecular Weight: 164.1332
• Mol File: 704-97-2.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 304.457°C at 760 mmHg
• Flash Point: 137.931°C
• Density: 1.343g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 3-(2-fluorophenyl)prop-2-ynoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-fluorophenyl)prop-2-ynoic acid(704-97-2)
• EPA Substance Registry System: 3-(2-fluorophenyl)prop-2-ynoic acid(704-97-2)

Safety Data

• Hazardous Substances Data: 704-97-2(Hazardous Substances Data)

Usage

General Description

3-(2-fluorophenyl)prop-2-ynoic acid is a chemical compound with the molecular formula C9H7FO2. It is a propiolic acid derivative containing a fluorophenyl group. 3-(2-fluorophenyl)prop-2-ynoic acid is a known inhibitor of antiangiogenic properties, and it has been studied for its potential pharmacological properties, particularly in the treatment of cancer. Additionally, it has been investigated for its potential use as a building block in organic synthesis for the production of various chemical compounds. The chemical structure of 3-(2-fluorophenyl)prop-2-ynoic acid makes it a versatile compound for use in various scientific and industrial applications.

Upstream product

• 348-52-7 1-Fluoro-2-iodobenzene 
• 471-25-0 Propiolic acid 
• 340772-55-6 methyl 3-(2-fluorophenyl)prop-2-ynoate 
• 1072-85-1 o-fluorobromobenzene 
• 480439-33-6 ((2-fluorophenyl)ethynyl)trimethylsilane 
• 124-38-9 carbon dioxide 
• 58686-74-1 ethyl 3-(2-fluorophenyl)propiolate 
• 766-49-4 (2-fluorophenyl)acetylene 

Downstream Products

• 633327-38-5 (E)-2-(2-fluorostyryl)-4,4,5,5-tetramethyl-1,3-dioxa-2-borolane 

Relevant articles and documents

Cobalt-Mediated Decarboxylative/Desilylative C?H Activation/Annulation Reaction: An Efficient Approach to Natural Alkaloids and New Structural Analogues

A Co(II)-mediated decarboxylative/desilylative C?H activation/annulation reaction for the efficient synthesis of 3-arylisoquinolines has been developed. Using alkynyl carboxylic acid and alkynyl silane as terminal alkyne precursors, providing straightforw

Microwave-assisted fabrication of a mixed-ligand [Cu4(μ3-OH)2]-cluster-based metal–organic framework with coordinatively unsaturated metal sites for carboxylation of terminal alkynes with carbon dioxide

The development of efficient and stable metal–organic framework (MOF) catalysts with coordinatively unsaturated metal sites for modern organic synthesis is greatly important. Herein, a robust [Cu4(μ3-OH)2]-cluster-based MOF (Cu-MOF) with a mixed-ligand system was successfully fabricated by a microwave-assisted method under mild conditions. The as-prepared Cu-MOF catalyst possessing unsaturated Cu (II) sites exhibited excellent catalytic activity toward the direct carboxylation of 1-ethynylbenzene with CO2, and various propiolic acid derivatives were synthesized in moderate to good yields under optimized reaction conditions. Furthermore, the catalyst remained stable and could be easily recycled for five sequential runs without incredible decrease in catalytic efficiency.

Visible light induced 3-position-selective addition of arylpropiolic acids with ethersviaC(sp3)-H functionalization

Although the 2-position-selective decarboxylative coupling or addition of arylpropiolic acids with cyclic ethers has been intensively investigated, selective functionalization of arylpropiolic acids at the 3-position is still a big challenge. Herein, an i