70432-25-6

Basic information

• Product Name: 3-Isoxazolecarboxylicacid,4,5-dihydro-5-oxo-,ethylester(9CI)
• Synonyms: 3-Isoxazolecarboxylicacid,4,5-dihydro-5-oxo-,ethylester(9CI);Ethyl 5-oxo-4,5-dihydroisoxazole-3-carboxylate;3-Isoxazolecarboxylic acid, 4,5-dihydro-5-oxo-, ethyl ester
• CAS NO: 70432-25-6
• Molecular Formula: C6H7NO4
• Molecular Weight: 157.12
• Product Categories: OXAZOLE
• Mol File: 70432-25-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 205.7±23.0 °C(Predicted)
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Isoxazolecarboxylicacid,4,5-dihydro-5-oxo-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isoxazolecarboxylicacid,4,5-dihydro-5-oxo-,ethylester(9CI)(70432-25-6)
• EPA Substance Registry System: 3-Isoxazolecarboxylicacid,4,5-dihydro-5-oxo-,ethylester(9CI)(70432-25-6)

Safety Data

• Hazardous Substances Data: 70432-25-6(Hazardous Substances Data)

Usage

Molecular Weight

153.136 g/mol

Chemical Structure

The compound is an ethyl ester derivative of 3-Isoxazolecarboxylic acid.

Applications in Pharmaceutical Industry

Commonly used in the synthesis of various drugs and pharmaceutical products.

Biological Activities

Antimicrobial Properties: Exhibits potential antimicrobial activity.
Antifungal Properties: Demonstrates potential antifungal activity.

Usage in Drug Discovery and Development

Serves as a valuable building block in drug discovery and development processes.

Safety Precautions

Important to handle with caution, as improper usage can lead to hazards.

Upstream product

• 40876-98-0 sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate 
• 97149-56-9 4,4-dimethoxy-but-3-enoic acid ethyl ester 
• 56579-54-5 Ethyl 2,2-dimethoxycyclopropane-1-carboxylate 

Downstream Products

• 1914946-33-0 ethyl 5-bromoisoxazole-3-carboxylate 
• 70432-37-0 4-[(3-ethoxycarbonyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-5-oxo-2,5-dihydro-isoxazole-3-carboxylic acid ethyl ester 
• 70432-28-9 5-oxo-4-(triphenyl-λ⁵-phosphanylidenehydrazono)-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester 
• 70432-33-6 4-[(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-hydrazino]-5-oxo-2,5-dihydro-isoxazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Expeditious Lead Optimization of Isoxazole-Containing Influenza A Virus M2-S31N Inhibitors Using the Suzuki-Miyaura Cross-Coupling Reaction

The existence of multidrug-resistant influenza viruses, coupled with the continuously antigenic shift and antigenic drift of influenza viruses, necessitates the development of the next-generation of influenza antivirals. As the AM2-S31N mutant persists in more than 95% of current circulating influenza A viruses, targeting the AM2-S31N proton channel appears to be a logical and valid approach to combating drug resistance. Starting from compound 1, an isoxazole compound with potent AM2-S31N channel blockage and antiviral activity, in this study we report an expeditious synthetic strategy that allows us to promptly explore the structure-activity relationships of isoxazole-containing AM2-S31N inhibitors. Propelled by the convenient synthesis, the lead optimization effort yielded a number of potent antivirals with submicromolar efficacy against several human clinical isolates of influenza A viruses, including both oseltamivir-sensitive and -resistant strains.