7065-92-1

Basic information

• Product Name: 2-CHLORO-3-PHENYLQUINOXALINE
• Synonyms: 2-CHLORO-3-PHENYLQUINOXALINE;2-Chloro-3-phenylquinoxaline（WS203325）
• CAS NO: 7065-92-1
• Molecular Formula: C₁₄H₉ClN₂
• Molecular Weight: 240.69
• Mol File: 7065-92-1.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 564.9°C at 760 mmHg
• Flash Point: 295.4°C
• Appearance: /
• Density: 1.355g/cm³
• Vapor Pressure: 8.8E-13mmHg at 25°C
• Refractive Index: 1.616
• PKA: -2.14±0.48(Predicted)
• CAS DataBase Reference: 2-CHLORO-3-PHENYLQUINOXALINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-PHENYLQUINOXALINE(7065-92-1)
• EPA Substance Registry System: 2-CHLORO-3-PHENYLQUINOXALINE(7065-92-1)

Safety Data

• Hazardous Substances Data: 7065-92-1(Hazardous Substances Data)

Usage

General Description

2-CHLORO-3-PHENYLQUINOXALINE is a chemical compound with the molecular formula C14H8ClNO. It is a yellow solid with a molecular weight of 253.67 g/mol. 2-CHLORO-3-PHENYLQUINOXALINE is classified as a quinoxaline derivative, which is a class of organic compounds containing a dibenzo-1,4-diazine ring. 2-CHLORO-3-PHENYLQUINOXALINE is used in organic synthesis and medicinal chemistry research, particularly in the development of pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable building block for the synthesis of various biologically active compounds and materials.

InChI:InChI=1/C17H19N3O4S/c1-13(21)14-3-2-4-15(11-14)19-17-6-5-16(12-18-17)25(22,23)20-7-9-24-10-8-20/h2-6,11-12H,7-10H2,1H3,(H,18,19)

Upstream product

• 2213-63-0 2,3-dichloroquinoxaline 
• 98-80-6 phenylboronic acid 
• 611-73-4 Benzoylformic acid 
• 95-54-5 1,2-diamino-benzene 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 15804-19-0 quinoxaline-2,3-dione 
• 88-74-4 2-nitro-aniline 
• 532-27-4 1-chloroacetophenone 
• 62-53-3 aniline 
• 1504-78-5 3-phenylquinoxaline-2(1H)-one 
• 1504-78-5 2-hydroxy-3-phenylquinoxaline 

Downstream Products

• 1025-22-5 2-hydrazino-3-phenylquinoxaline 
• 33507-89-0 2-methoxy-3-phenylquinoxaline 
• 709638-30-2 [4-(3-phenyl-quinoxalin-2-yloxy)-phenyl]-acetic acid methyl ester 
• 912363-53-2 2-ethoxycarbonylmethylthio-3-phenylquinoxaline 
• 1009737-39-6 2-iodo-3-phenylquinoxaline 
• 1009737-51-2 N,N-dimethyl-2-(3-phenyl-quinoxalin-2-yl)-acetamide 
• 476374-27-3 [4-(3-phenyl-quinoxalin-2-ylamino)-phenyl]-acetic acid 
• 476374-13-7 (S)-2-{2-[4-(3-Phenyl-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester 
• 361390-13-8 2-(3-phenylquinoxalin-2-ylamino)-4,5-dimethoxybenzoic acid 
• 53047-74-8 C₁₉H₂₀N₄ 
• 1621905-65-4 1-(3-phenylquinoxalin-2-yl)piperidin-4-ol 

Relevant articles and documents

Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein

Quinoxaline is one of the privileged heterocyclic fragments for drug molecules. Quinoxaline anticancer drug candidates XK469 and CQS exhibit antiproliferative and proapoptotic properties against various cancers. Based on their chemical structures, we therefore synthesized a series of quinoxaline-1,3,4-oxadiazole hybrids and assessed their anticancer potential on human leukemia HL-60 cells. Although these hybrids exerted significant inhibition of HL-60 cell proliferation, they showed high cytotoxicity on human normal cells (WI-38). Utilizing information from molecular modelling of the hybrids to the anti-apoptotic Bcl-2 protein, we added substructures including phenyl, piperazine, piperidine, and morpholine rings to their frameworks. The designed quinoxaline-1,3,4-oxadiazole hybrid derivatives successfully induced apoptotic response on HL-60 cells with low toxicity on WI-38 cells. Furthermore, RT-PCR analysis demonstrated that these derivatives predominantly inhibit Bcl-2 expression. Our findings highlight the great potential for the development of synthetic quinoxaline-1,3,4-oxadiazole hybrid derivatives as proapoptotic anticancer agents.

NOVEL COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME

The present invention relates to a novel compound, capable of improving efficiency, and low driving voltage and/or lifespan characteristics in an organic light emitting device, and to an organic light emitting device including the same. The novel compound

1,2,4-triazole derivative having quinoxaline structure, preparation method and application thereof

The invention discloses a 1,2,4-triazole derivative having quinoxaline structure, a preparation method and an application thereof. O-nitroaniline and hydrazine hydrate react to form a compound (II). The compound (II) reacts with MBF to prepare a compound