707-37-9

Basic information

• Product Name: 3,5-Dimethyl-1-adamantanol
• Synonyms: 3,5-DIMETHYL-1-ADAMANTANOL;AKOS BC-0635;1-Hydroxy-3,5-dimethyladamantane;1,3-Dimethyl-5-hydroxyadamantane;1,3-DiMethyl-5-adaMantanol;3,5-DiMethyl-1-hydroxyadaMantane;3,5-DiMethyltricyclo[3.3.1.13,7]decan-1-ol;NSC 102294
• CAS NO: 707-37-9
• Molecular Formula: C₁₂H₂₀O
• Molecular Weight: 180.29
• EINECS: 1312995-182-4
• Product Categories: Adamantane derivatives;Adamantanes;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 707-37-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 95 °C
• Boiling Point: 247.166 °C at 760 mmHg
• Flash Point: 101.766 °C
• Appearance: /
• Density: 1.122 g/cm³
• Vapor Pressure: 0.00426mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 15.41±0.60(Predicted)
• CAS DataBase Reference: 3,5-Dimethyl-1-adamantanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dimethyl-1-adamantanol(707-37-9)
• EPA Substance Registry System: 3,5-Dimethyl-1-adamantanol(707-37-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 707-37-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 707-37-9 differently. You can refer to the following data:
1. 3,5-Dimethyl-1-adamantanol is an impurity of Memantine (M218000). Memantine impurity B. Memantine USP Related Compound B (3,5-Dimethyladamantane-1-ol).
2. 3,5-Dimethyl-1-adamantanol is an impurity of Memantine (M218000). Memantine impurity B.

InChI:InChI=1/C12H20O/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9,13H,3-8H2,1-2H3

Upstream product

• 702-79-4 1,3-dimethyladamantane 
• 876-53-9 1,3-dibromoadamantane 
• 101821-77-6 3,5-dimethyladamantan-1-yl nitrate 
• 19982-07-1 1-acetamido-3,5-dimethyladamantane 
• 941-37-7 3,5-dimethyl-1-bromoadamantane 
• 77287-34-4 formamide 
• 524-38-9 N-hydroxyphthalimide 

Downstream Products

• 14202-14-3 acide dimethyl-3,5 adamantylacetique 
• 941-37-7 3,5-dimethyl-1-bromoadamantane 
• 351329-88-9 1-formamido-3,5-dimethyltricyclo[3.3.1.1^3,7]decane 
• 41100-52-1 memantine hydrochloride 
• 14670-94-1 3,5-dimethyl-1-adamantanecarboxylic acid 
• 356572-08-2 1-hydroxy-3-amino-5,7-dimethyladamantane hydrochloride 
• 63971-25-5 3-amino-5,7-dimethyladamantan-1-ol 
• 702-79-4 1,3-dimethyladamantane 
• 941-37-7 3,5-dimethyl-1-bromoadamantane 
• 707-36-8 1-chloro-3,5-dimethyl-adamantane 
• 21912-23-2 1,3?dibromo?5,7?dimethyladamantane 
• 50847-70-6 2-(3,5-Dimethyl-1-adamantyl)-ethanol-1 
• 19982-08-2 memantine 
• 19982-07-1 1-acetamido-3,5-dimethyladamantane 

Relevant articles and documents

Synthesis of 3,5-dimethyladamantan-1-ol by reaction of 1,3- dimethyladamantane with bromotrichloromethane and water in the presence of manganese complexes

3,5-Dimethyladamantan-1-ol was synthesized in 79% yield by reaction of 1,3-dimethyladamantane with bromotrichloromethane and water in the presence of manganese salts and complexes activated by pyridine.

Method for oxidizing adamantane

PROBLEM TO BE SOLVED: To provide a method for easily and efficiently producing 1,3-dihydroxy adamantane being a compound extremely important as a material for a bifunctional monomer. SOLUTION: A method for producing 1,3-dihydroxy adamantane includes oxidation of adamantane by ozone in solvent containing 60-100 wt.% carboxylic acid of C1-C4, in the presence of an organic molecule catalyst and a transition metal catalyst. The method for producing 1,3-dihydroxy adamantane employs N-hydroxy succinic imide or organic nitroxyl radical compound as the organic molecule catalyst, and cobalt acetate etc. as the transition metal catalyst, to promote reaction. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPO&INPIT

PROCESS FOR PREPARING MEMANTINE

A process for preparing memantine or an acid addition salt of memantine comprises reacting 1-bromo-3,5-dimethyl adamantane with formamide to form 1-N-formyl-3,5-dimethyl adamantane.