70717-76-9

Basic information

• Product Name: BOC-D-VAL-NH2
• Synonyms: BOC-D-VAL-NH2;Boc-D-valine amide;N-tert-Butoxycarbonyl-D-valine amide;Tyr(Me)-OMe.HCl;(R)-tert-Butyl (1-amino-3-methyl-1-oxobutan-2-yl)carbamate
• CAS NO: 70717-76-9
• Molecular Formula: C₁₀H₂₀N₂O₃
• Molecular Weight: 216.279
• Mol File: 70717-76-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 156-157 °C
• Boiling Point: 361.7 °C at 760 mmHg
• Flash Point: 172.6 °C
• Appearance: /
• Density: 1.042
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.463
• Storage Temp.: 2-8°C
• PKA: 11.30±0.46(Predicted)
• CAS DataBase Reference: BOC-D-VAL-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-VAL-NH2(70717-76-9)
• EPA Substance Registry System: BOC-D-VAL-NH2(70717-76-9)

Safety Data

• Hazardous Substances Data: 70717-76-9(Hazardous Substances Data)

Usage

General Description

BOC-D-VAL-NH2 is a chemical compound consisting of a valine molecule (VAL) attached to an amino group (NH2) and protected by a tert-butoxycarbonyl (BOC) group. BOC-D-VAL-NH2 is commonly used in peptide synthesis as a building block in the creation of peptides and proteins. The BOC protecting group is used to prevent unwanted reactions at the amino group, allowing for specific reactions to occur at the valine residue. BOC-D-VAL-NH2 is a key component in the production of custom peptides and plays an important role in biochemical research and pharmaceutical development.

InChI:InChI=1/C10H20N2O3/c1-6(2)7(8(11)13)12-9(14)15-10(3,4)5/h6-7H,1-5H3,(H2,11,13)(H,12,14)/t7-/m1/s1

Upstream product

• 128211-52-9 (3S)-3-N-(tert-butyloxycarbonyl)amino-4-methylpentan-2-one 
• 22838-58-0 Boc-D-Val-OH 

Downstream Products

• 625840-35-9 [(R)-1-(N-benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid t-butyl ester 
• 1044661-22-4 1,1-dimethylethyl [2-(acryloyl{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate 
• 851635-10-4 1,1-dimethylethyl [2-({1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate 
• 851635-07-9 5-methyl-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile 
• 1044661-23-5 N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide 
• 625840-39-3 [1-(3-benzyl-5-methyl-6-cyano-4-oxo-3,4-dihydro-pyrimidin-2-yl)-2-methyl-propyl]-carbamic acid-t-butyl ester 
• 851635-09-1 2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile 
• 186453-48-5 2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester 
• 32526-16-2 D-valine amide 
• 142055-86-5 (R)-(1-cyano-2-methyl-propyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis of the Bycroft-Gowland structure of micrococcin P1

(formula presented) We describe the chemical synthesis of the accepted structure of micrococcin P1, a member of the thiostrepton group of antibiotics, and we show that this architecture does not correspond to that of the natural product. Methods developed during the present study should greatly facilitate ongoing efforts centering on the determination of the actual structure of microccin P1, in addition to being applicable to the synthesis of more complex thiostrepton congeners.

RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles

The established cytotoxic agent RITA contains a thiophene-furan-thiophene backbone and two terminal alcohol groups. Herein we investigate the effect of using thiazoles as the backbone in RITA-like molecules and modifying the terminal groups of these trithiazoles, thereby generating 41 unique structures. Incorporating side chains with varied steric bulk allowed us to investigate how size and a stereocenter impacted biological activity. Subjecting compounds to growth inhibition assays on HCT-116 cells showed that the most potent compounds 7d, 7e, and 7h had GI50 values of 4.4, 4.4, and 3.4 μM, respectively, versus RITA (GI50 of 800 nM). Analysis of these compounds in apoptosis assays proved that 7d, 7e, and 7h were as effective as RITA at inducing apoptosis. Evaluating the impact of 7h on proteins targeted by RITA (p53, c-Myc, and Mcl-1) indicated that it acts via a different mechanism of action to that of RITA. RITA suppressed Mcl-1 protein via p53, whereas compound 7h suppressed Mcl-1 expression via an alternative mechanism independent of p53.

Total synthesis and complete structural assignment of Yaku'amide A

Here we report the first total synthesis and the complete stereochemical assignment of yaku'amide A. Yaku'amide A (1) was isolated from a sponge Ceratopsion sp. as an extremely potent cytotoxin. Its structure was determined except for the C4-stereochemist