70753-36-5Relevant articles and documents
CONDENSED AZINES FOR EP300 OR CBP MODULATION AND INDICATIONS THEREFOR
-
, (2020/10/21)
Disclosed are compounds of Formula I or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein A1, A2, A3, A4, R4, X1, X2, and X3 are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
Hydroboration-azide alkylation as efficient tandem reactions for the synthesis of chiral non racemic substituted pyrrolidines
Salmon, Anne,Carboni, Bertrand
, p. 31 - 37 (2007/10/03)
The synthesis of chiral non racemic substituted pyrrolidines from homoallylic alcohols is presented. These precursors are readily converted via the azides to the corresponding pyrrolidines using hydroboration-cycloalkylation tandem reactions as key steps.
Stereoselectivity in the Peterson reaction - Application to the synthesis of BRL 49467
Bell, David,Crowe, Eleanor A.,Dixon, Nicholas J.,Geen, Graham R.,Mann, Inderjit S.,Shipton, Mark R.
, p. 6643 - 6652 (2007/10/02)
The E:Z selectivity in the introduction of the tri-substituted double bond in BRL 49467 could be controlled by the choice of base and silyl group used in a Peterson olefination reaction. The method allowing optimum E-selectivity was developed such that it