708-76-9Relevant articles and documents
The synthesis of atalantrenes B, C and D, styrene-dimers from the seeds of Atalantia monophylla
Nielsen, Alexander J.,Deng, Zirou,McNulty, James
, (2020/12/28)
Concise syntheses of three recently reported natural products from Atalantia monophylla are reported. The syntheses required the preparation and careful dimerization of highly electron rich styrenes under acidic conditions. The present work adds to a growing body of evidence that demonstrates that synthetic utility of chiral phosphoric acids in asymmetric reactions using styrene-type compounds.
METHODS OF TREATING CANCER WITH SMALL MOLECULE NF-kB INHIBITORS
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Paragraph 0433, (2019/01/15)
The present invention provides, inter alia, compounds capable of inhibiting NF-κB. Pharmaceutical compositions containing and methods of using the compounds are also provided herein. Also provided are methods and kits for treating cancer and solid tumors in a subject, as well as methods and kits for inducing cancer cell death and apoptosis of a cancer cell, all utilizing the NF-κB inhibitors described herein.
An Optimized Preparation of 1,1-Dimethylallyl Esters and Their Application to Solid-Phase Peptide Synthesis
Hostetler, Matthew A.,Lipton, Mark A.
, p. 7762 - 7770 (2018/07/05)
A one-step preparation of 1,1-dimethylallyl (DMA) esters was optimized for the C-terminal protection of a range of Fmoc-protected amino acids. This preparation is not sensitive to the scale of reaction and affords the corresponding DMA esters in 70-99% yield with high regioselectivity. Additionally, these DMA-protected amino acids were used with the backbone amide linker (BAL) of Albericio and Barany and found to resist diketopiperazine formation during the synthesis of a series of tripeptide esters. C-terminal DMA protection is compatible with the BAL linkage and allows for standard Fmoc-based methods to be used throughout the synthesis.