7085-55-4Relevant articles and documents
Troxerutin compound
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Paragraph 0050-0052; 0061-0065, (2020/01/14)
The invention discloses a troxerutin compound prepared by using an advanced on-line process control technology. The troxerutin compound is measured by X-ray powder diffraction, and a X-ray powder diffraction pattern expressed by a 2 diffraction angle shows characteristic diffraction peaks at the 2 of 8.15+/-0.2 degrees, 9.24+/-0.2 degrees, 12.31+/-0.2 degrees, 17.10+/-0.2 degrees, 17.92+/-0.2 degrees, 18.73+/-0.2 degrees and 23.45+/-0.2 degrees. The compound has the characteristics of high purity, low impurity content, good fluidity and good stability.
A self-priming stirred autoclave preparation of troxerutin method
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Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0031, (2017/06/29)
The invention discloses a method for preparing troxerutin by adopting a self-suction type stirred autoclave. The method comprises the following steps: adding raw materials namely rutin, ethylene oxide, a solvent namely methanol and a catalyst namely natural weakly-alkaline high-molecular compound chitosan into a self-suction type stirred autoclave, starting a digital control instrument, setting a temperature to be 70-90 DEG C, regulating a voltage to be 100V, setting a rotating speed to be 1000r/min, stirring and heating to reach a set temperature, and reacting for 3-6 hours; and stopping stirring after reaction is ended, rapidly cooling by using cold water, shutting down the digital control instrument, opening a reaction kettle, pouring out reaction liquid, adjusting a pH value of the poured reaction liquid to be 5-6 by using hydrochloric acid, performing suction filtration, adding a crystal seed into the reaction liquid subjected to suction filtration, standing for later crystallization, and filtering to obtain a product namely troxerutin. According to the method disclosed by the invention, the reaction raw materials are integrally added into the self-suction type stirred autoclave, so that material feeding steps can be simplified; and the adopted catalyst is natural weakly-alkaline high-molecular compound chitosan, so that the raw material is wide in source, and is natural, non-toxic and weakly-alkaline, and side reactions such as hydrolysis, oxidation and the like caused by strong alkaline catalysis can be avoided.
A high-purity of troxerutin preparation method
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Paragraph 0013; 0014, (2017/07/01)
The invention discloses a preparation method of high-purity troxerutin. According to the preparation method of the high-purity troxerutin, the synthesis and refining processes of the troxerutin are improved; sodium methoxide or sodium ethoxide is selected as a catalyst, supercritical CO2 is selected for extraction and crystallization refining of the troxerutin, and finally, the troxerutin of which the yield and the purity both are greatly improved in contrast with a traditional process can be obtained.