70918-74-0

Basic information

• Product Name: 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride
• Synonyms: (2,3-Dihydrobenzo[1.4]dioxin-2-yl)piperazine-1-yl-methanone;N-(2,3-Dihydro-1,4-Benzodioxane-2-Carbonyl)Piperazine HCl;N-(1,4-Benzodioxan-2-carbonyl)piperazine hydrochloride 98%;(2,3-Dihydro-benzo[1,4]dioxin-2-yl)piperazine-;N-(1,4-BENZODIOXANE-2-CARBONYL) PIPERAZINE DIHYDRO;1-(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLCARBONYL)PIPERAZINE HCL;1-(1,4-benzodioxan-2-ylcarbonyl)piperazine hydrochloride;N-[(1,4-Benzodioxin-2-yl)carbonyl]piperazine hydrochloride
• CAS NO: 70918-74-0
• Molecular Formula: C₁₃H₁₆N₂O₃*ClH
• Molecular Weight: 284.74
• EINECS: 415-660-9
• Product Categories: Piperidines, Piperidones, Piperazines;(intermediate of doxazosin);(intermediate of doxazocin mesylate)
• Mol File: 70918-74-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 105-108°C
• Boiling Point: 437.2 °C at 760 mmHg
• Flash Point: 218.2 °C
• Appearance: white or white like crystalline powder
• Vapor Pressure: 7.62E-08mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride(70918-74-0)
• EPA Substance Registry System: 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride(70918-74-0)

Safety Data

• Hazard Codes: T;N,Xi,N,T
• Statements: 23/24/25-48/22-51/53
• Safety Statements: 45-53-61
• RIDADR: UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s.,
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 70918-74-0(Hazardous Substances Data)

Usage

General Description

1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride is a chemical compound that consists of a piperazine molecule with a hydrochloride salt attached to it, as well as a benzodioxin ring. The benzodioxin ring is a heterocyclic compound with a dioxane structure, and the piperazine molecule is a heterocyclic amine with potential pharmaceutical applications. 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride has been studied for its potential use as a drug with various psychoactive and therapeutic effects, and its structure suggests that it may interact with neurotransmitter receptors in the brain. However, further research is necessary to fully understand its pharmacological properties and potential uses in medicine.

InChI:InChI=1/C13H16N2O3.ClH/c16-13(15-7-5-14-6-8-15)12-9-17-10-3-1-2-4-11(10)18-12;/h1-4,12,14H,5-9H2;1H

Upstream product

• 110-85-0 piperazine 
• 3663-81-8 1,4-benzodioxan-2-carbonyl chloride 
• 4739-94-0 ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate 
• 3663-82-9 2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin 

Relevant articles and documents

An improved one-pot synthesis of N-(2,3-dihydrobenzo[1,4]dioxin-2-carbonyl) piperazine - Useful intermediate for anti-hypertensive drug - Doxazosin

An improved process for the preparation of N-(2,3-dihydrobenzo[1,4]dioxin- 2-carbonyl)piperazine 2 and its hydrochloride from ethyl-2,3-dihydro-1,4- benzodioxin-2-carboxylate 3 and piperazine in a single step has been described. The compound 2 is an important intermediate in the preparation of anti-hypertensive agent, Doxazosin.

2,4-Diamino-6,7-dimethoxyquinazolines. 1. 2-[4-(1,4-benzodioxan-2-ylcarbonyl)piperazin-1-yl] derivatives as α1-adrenoceptor antagonists and antihypertensive agents

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Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines

Compounds having the formula STR1 and pharmaceutically acceptable salts thereof wherein R represents 6,7-di(lower alkoxy) or 6,7,8-tri(lower alkoxy); m is 1 or 2, X is --CHR1 -- or --CH2 CH2 --; each R1 and R0 may be the same or different and is hydrogen or lower alkyl; each of R2 and R3 is hydrogen, lower alkoxy, lower alkyl, halogen, lower alkanoyl, lower alkoxycarbonyl, --CONR4 R5 or --SO2 NR4 R5 wherein each of R4 and R5 is hydrogen or lower alkyl; processes for their preparation; and their use as regulators of the cardiovascular system, and particularly in the treatment of hypertension.