7095-08-1

Basic information

• Product Name: 1,6-dihydronicotinamide adenine dinucleotide
• Synonyms: 1,6-dihydronicotinamide adenine dinucleotide
• CAS NO: 7095-08-1
• Molecular Weight: 665.447
• Mol File: 7095-08-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,6-dihydronicotinamide adenine dinucleotide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-dihydronicotinamide adenine dinucleotide(7095-08-1)
• EPA Substance Registry System: 1,6-dihydronicotinamide adenine dinucleotide(7095-08-1)

Safety Data

• Hazardous Substances Data: 7095-08-1(Hazardous Substances Data)

Upstream product

• 53-84-9 NAD 

Relevant articles and documents

Chemo-bio catalysis using carbon supports: application in H2-driven cofactor recycling

Heterogeneous biocatalytic hydrogenation is an attractive strategy for clean, enantioselective CX reduction. This approach relies on enzymes powered by H2-driven NADH recycling. Commercially available carbon-supported metal (metal/C) catalysts are investigated here for direct H2-driven NAD+reduction. Selected metal/C catalysts are then used for H2oxidation with electrons transferredviathe conductive carbon support material to an adsorbed enzyme for NAD+reduction. These chemo-bio catalysts show improved activity and selectivity for generating bioactive NADH under ambient reaction conditions compared to metal/C catalysts. The metal/C catalysts and carbon support materials (all activated carbon or carbon black) are characterised to probe which properties potentially influence catalyst activity. The optimised chemo-bio catalysts are then used to supply NADH to an alcohol dehydrogenase for enantioselective (>99% ee) ketone reductions, leading to high cofactor turnover numbers and Pd and NAD+reductase activities of 441 h?1and 2347 h?1, respectively. This method demonstrates a new way of combining chemo- and biocatalysis on carbon supports, highlighted here for selective hydrogenation reactions.