70978-54-0

Basic information

• Product Name: 5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE
• Synonyms: 1-(5-BROMO-2-HYDROXY-3-NITROPHENYL)ETHANONE;3-BROMO-6-HYDROXY-5-NITRO ACETOPHENONE;5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE;5-BROMO-2-HYDROXY-3-NITROACETOPHENONE;5'-Bromo-3'-nitro-2'-hydroxyacetophenone
• CAS NO: 70978-54-0
• Molecular Formula: C₈H₆BrNO₄
• Molecular Weight: 260.04
• Product Categories: Ketones;Organic Building Blocks;Aromatic Acetophenones & Derivatives (substituted);Building Blocks;C7 to C8;Carbonyl Compounds;Chemical Synthesis
• Mol File: 70978-54-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 129-132 °C(lit.)
• Boiling Point: 272.9℃
• Flash Point: 118.9℃
• Appearance: /
• Density: 1.763
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 6.47±0.38(Predicted)
• CAS DataBase Reference: 5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE(70978-54-0)
• EPA Substance Registry System: 5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE(70978-54-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 70978-54-0(Hazardous Substances Data)

Usage

Uses

5'-Bromo-2'-hydroxy-3'-nitroacetophenone is used as a chemical reagent in the synthesis of amides and benzoxazoles directly using a sulfate catalyst and microwaves. 1-(5-Bromo-2-hydroxy-3-nitrophen yl)ethanone is used in studies involving HIV-1 integrase inhibitors.

Preparation

Preparation by nitration of 5-bromo-2-hydroxyacetophenone in refluxing carbon tetrachloride (88%).

Upstream product

• 1450-75-5 5-Bromo-2-hydroxyacetophenone 

Downstream Products

• 474554-55-7 1-(5-bromo-2-methoxy-3-nitrophenyl)-1-ethanone 
• 1449688-60-1 C₂₅H₂₈BrNO₆Si 
• 1449688-61-2 C₂₀H₁₃⁽³⁾H₃BrNO₆ 
• 1450590-56-3 C₁₈H₉⁽³⁾H₃BrNO₆ 
• 1449688-70-3 C₁₈H₁₁BrFNO₆ 
• 1449688-71-4 C₁₈H₁₁BrFNO₆ 
• 1449688-72-5 C₁₈H₁₀BrF₂NO₆ 
• 1449688-64-5 C₂₀H₁₅BrFNO₆ 
• 1449688-65-6 C₂₀H₁₅BrFNO₆ 
• 1449688-66-7 C₂₀H₁₄BrF₂NO₆ 
• 1448010-29-4 1-(2-hydroxy-5-(6-methoxynaphthalen-2-yl)-3-nitrophenyl)ethanone 
• 1441772-25-3 6-bromo-3-hydroxy-8-nitro-2-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one 
• 1441774-65-7 C₁₈H₁₆BrNO₇ 
• 1443367-25-6 6-bromo-8-(2-chloro-4-methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic acid 

Relevant articles and documents

ANTI-INFECTIVE AGENTS

The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and their use as anti-infective agents in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

Benzopyran derivatives having leukotriene-antagonistic action

The present invention relates to novel 4-oxo-4H-1-benzopyran compounds containing benzyloxymethyl, 3-phenylpropyl, or other araliphatic substituents in their 8-position. These compounds show a leukotriene-antagonistic activity. The compounds are characterized by good oral adsorption. The compounds of the present invention may be used as anti-inflammatory and antiallergic medicaments, and in the treatment of cardiovascular diseases.