71056-58-1

Basic information

• Product Name: ethyl 5-amino-1-methyl-1H-indole-2-carboxylate
• Synonyms: ethyl 5-amino-1-methyl-1H-indole-2-carboxylate;5-Amino-1-methyl-1H-indole-2-carboxylic acid ethyl ester;N-Methyl-5-aminoindole-2-carboxylic acid ethyl ester;1H-Indole-2-carboxylic acid,5-amino-1-methyl-,ethyl ester
• CAS NO: 71056-58-1
• Molecular Formula: C₁₂H₁₄N₂O₂
• Molecular Weight: 218.255
• Mol File: 71056-58-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 79-80℃
• Boiling Point: 404.8°C at 760 mmHg
• Flash Point: 198.6°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 9.17E-07mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: ethyl 5-amino-1-methyl-1H-indole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-amino-1-methyl-1H-indole-2-carboxylate(71056-58-1)
• EPA Substance Registry System: ethyl 5-amino-1-methyl-1H-indole-2-carboxylate(71056-58-1)

Safety Data

• Hazardous Substances Data: 71056-58-1(Hazardous Substances Data)

Usage

Description

Ethyl 5-amino-1-methyl-1H-indole-2-carboxylate, also known as AMI-1, is a chemical compound with the molecular formula C13H15N3O2. It is a synthetic intermediate used in the production of pharmaceuticals and organic compounds. AMI-1 is a derivative of indole, a heterocyclic organic compound, and has a variety of potential applications in medicinal chemistry and drug development. Its structure contains an ester group, an amino group, and a methyl group, making it a versatile building block for creating new chemical entities with potential biological activity. AMI-1 is known for its ability to modulate enzyme activity and protein-protein interactions, making it a valuable tool in biomedical research and drug discovery.

Uses

Used in Pharmaceutical Industry:
Ethyl 5-amino-1-methyl-1H-indole-2-carboxylate is used as a synthetic intermediate for the production of pharmaceuticals and organic compounds. Its versatile structure allows for the creation of new chemical entities with potential biological activity, making it a valuable building block in drug development.
Used in Medicinal Chemistry:
Ethyl 5-amino-1-methyl-1H-indole-2-carboxylate is used as a versatile building block in medicinal chemistry for creating new chemical entities with potential biological activity. Its ability to modulate enzyme activity and protein-protein interactions makes it a valuable tool in the development of new drugs and therapies.
Used in Biomedical Research:
Ethyl 5-amino-1-methyl-1H-indole-2-carboxylate is used as a valuable tool in biomedical research for modulating enzyme activity and protein-protein interactions. Its unique structure and properties make it useful in the study of various biological processes and the development of new therapeutic approaches.

InChI:InChI=1/C12H14N2O2/c1-3-16-12(15)11-7-8-6-9(13)4-5-10(8)14(11)2/h4-7H,3,13H2,1-2H3

Upstream product

• 71056-57-0 ethyl 1-methyl-5-nitro-1H-indole-2-carboxylate 

Downstream Products

• 294174-60-0 5-{4-[bis-(2-chloro-ethyl)-amino]-benzoylamino}-1-methyl-1H-indole-2-carboxylic acid ethyl ester 
• 481659-93-2 ethyl 1-methyl-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]-1H-indole-2-carboxylate 
• 481659-95-4 C₂₄H₁₇F₃N₂O₃ 
• 481658-94-0 Dirlotapide 
• 207845-98-5 5-{4-[bis-(2-chloro-ethyl)-amino]-benzoylamino}-1-methyl-1H-indole-2-carboxylic acid 
• 481660-07-5 5-(2-Acetoxy-benzoylamino)-1-methyl-1H-indole-2-carboxylic Acid Ethyl Ester 
• 167479-53-0 ethyl-5-benzamido-1-methyl-2-indolecarboxylate 
• 1314128-03-4 2-fluoro-N-[2-(hydroxymethyl)-1-methyl-1H-indol-5-yl]-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide 
• 1314128-04-5 2-fluoro-N-(2-formyl-1-methyl-1H-indol-5-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide 
• 1314128-05-6 4-bromo-N-[2-(hydroxymethyl)-1-methyl-1H-indol-5-yl]benzamide 
• 1314128-06-7 4-bromo-N-(2-formyl-1-methyl-1H-indol-5-yl)benzamide 
• 1314128-07-8 4-bromo-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide 
• 1314128-08-9 4-bromo-N-(2-{[(2,2-dimethylpropyl)amino]methyl}-1-methyl-1H-indol-5-yl)benzamide 
• 1314127-05-3 4-[(1-hydroxycyclobutyl)ethynyl]-N-(2-{[(2-methylpropyl)amino]methyl}-1-methyl-1H-indol-5-yl)benzamide 

Relevant articles and documents

1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE

A compound represented by formula (1) (in the formula: ring-D represents a three- to eight-membered hydrocarbon ring; Ra represents an optionally substituted amino C1-6 alkyl group or the like; Rb1 and Rb2 each independently represent a hydrogen atom, a halogen atom, or the like; Rc represents an optionally substituted C6-10 aryl group or the like; Rd represents a hydrogen atom or the like; and ring-Q represents a (hetero)aryl group or the like which may be substituted with a carboxyl group or the like) or a pharmaceutically acceptable salt thereof exhibits an excellent FXIa inhibitory activity, and is useful as a therapeutic agent against thrombosis or the like.

Viral polymerase inhibitors

An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I: wherein R1 is selected from: H, haloalkyl, (C1-6)alkyl, (C2-6)alkenyl, (C3-7)cycloalkyl, (C2-6)alkynyl, (C5-7)cycloalkenyl, 6 or 10-membered aryl, Het all optionally substituted; R2 is selected from (C1-6)alkyl, (C3-7)cycloalkyl, (C6-10)bicycloalkyl, 6- or 10-membered aryl, or Het all optionally substituted; B is N or CR5, wherein R5 is H, halogen, haloalkyl, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; X is N or CR5; D is N or CR5; each of Y1 and Y2 is independently O or S; Z is O, N, or NRz wherein Rz is H, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; R3 and R4 are each independently H, (C1-6)alkyl, first (C3-7)cycloalkyl or 6- or 10-membered aryl, Het (C1-6)alkyl-6- or 10-membered aryl, (C1-6)alkyl-Het; or each R3 and R4 are independently covalently bonded together to form second (C3-7)cycloalkyl, or heterocycle, all optionally substituted; or when Z is N, either R3 or R4 are independently covalently bonded thereto to form a nitrogen-containing heterocycle; R7 is H, (C1-6 alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; or R7 is covalently bonded to either of R3 or R4 to form a heterocycle; A is (C1-6) alkyl-CONHR8 wherein R8 is-6- or 10-membered aryl, or Het; or A is a 6- or 10-membered aryl, or Het said aryl or Het being optionally substituted; or a salt or a derivative thereof; such compounds being potent inhibitors of HCV NS5B polymerase.