71083-78-8

Basic information

• Product Name: 4-hydroxy-5,8-dimethoxyquinoline-3-carbonitrile
• Synonyms: 4-Hydroxy-5,8-dimethoxychinolin-3-carbonitril; 5,8-Dimethoxy-4-oxo-1,4-dihydrochinolin-3-carbonitril; 5,8-dimethoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile
• CAS NO: 71083-78-8
• Molecular Formula: C₁₂H₁₀N₂O₃
• Molecular Weight: 230.2194
• Mol File: 71083-78-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 461.4°C at 760 mmHg
• Flash Point: 232.9°C
• Density: 1.36g/cm³
• Vapor Pressure: 3.89E-09mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: 4-hydroxy-5,8-dimethoxyquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-5,8-dimethoxyquinoline-3-carbonitrile(71083-78-8)
• EPA Substance Registry System: 4-hydroxy-5,8-dimethoxyquinoline-3-carbonitrile(71083-78-8)

Safety Data

• Hazardous Substances Data: 71083-78-8(Hazardous Substances Data)

Upstream product

• 102-56-7 2,5-dimethoxyaniline 
• 208986-13-4 methyl 2-amino-3,6-dimethoxybenzoate 
• 20428-58-4 α-lithioacetonitrile 

Downstream Products

• 214476-68-3 4-chloro-5,8-dimethoxy-quinoline-3-carbonitrile 

Relevant articles and documents

Synthesis of 5,8-dimethoxy-3-hydroxy-4-quinolone, a reported inhibitor of HIV RT, and evidence the original proposed structure was incorrect

An unambiguous total synthesis of the title compound, a semi-synthetic derivative reported to be a non-nucleoside reverse transcriptase inhibitor, was conducted in four steps from 2,5-dimethoxyaniline. The synthetic material differed from that reported in the literature, both in its physical properties and 1H NMR spectrum. Biological evaluation indicated that synthetic 2 was inactive against HIV-1 RT, suggesting that the previous structural assignment of the semi-synthetic derivative was incorrect.