71258-18-9

Basic information

• Product Name: 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride
• Synonyms: N-BENZYL-4-CYANO-4PHENYLPIPERIDINE HCL;1-N-BENZYL-4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE;1-BENZYL-4-CYANO-4-PHENYLPIPERIDINE HCL;4-PHENYL-1-(PHENYLMETHYL)-4-PIPERIDINECARBONITRILE HCL;1-benzyl-4-phenylpiperidine-4-carbonitrile monohydrochloride;1-N-Benzyl-4-Cyano-4-Phenylpiperidine Hydrochloride 1;1-N-Benzyl-4-cyano-4-phenylpiperidineHCl;1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride
• CAS NO: 71258-18-9
• Molecular Formula: C₁₉H₂₀N₂*ClH
• Molecular Weight: 312.84
• EINECS: 275-305-7
• Product Categories: API intermediates;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 71258-18-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 257-261 °C
• Boiling Point: 430.4°C at 760 mmHg
• Flash Point: 184.3°C
• Appearance: /
• Vapor Pressure: 1.3E-07mmHg at 25°C
• CAS DataBase Reference: 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride(71258-18-9)
• EPA Substance Registry System: 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride(71258-18-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22
• Safety Statements: 45
• RIDADR: UN 3439 6.1/PG III
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 71258-18-9(Hazardous Substances Data)

Usage

Chemical Properties

White to beige powder

Uses

A piperidine derivative as calcium channel blockers.

InChI:InChI=1/C19H20N2/c20-16-19(18-9-5-2-6-10-18)11-13-21(14-12-19)15-17-7-3-1-4-8-17/h1-10H,11-15H2/p+1

Upstream product

• 56022-38-9 triethyl-hexadecyl-phosphonium; bromide 
• 140-29-4 phenylacetonitrile 
• 10429-82-0 N-benzyl-2-chloro-N-(2-chloroethyl)ethanamine hydrochloride 
• 55-51-6 N,N-bis(2-chloro-ethyl)-benzenemethanamine 

Downstream Products

• 3627-48-3 pethidinic acid 
• 1859-37-6 C-(1-methyl-4-phenyl-piperidin-4-yl)-methylamine 
• 3627-62-1 1-methyl-4-phenyl-piperidine-4-carbonitrile 
• 4220-10-4 (1-methyl-4-phenyl-piperidin-4-yl)-methanol 
• 57-42-1 pethidine 
• 40481-13-8 4-phenyl-4-cyanopiperidine 
• 862287-81-8 1-benzyl-4-phenyl-4-(2H-tetrazol-5-yl)-piperidine 
• 19015-37-3 1-(phenylmethyl)-4-phenylpiperidine 

Relevant articles and documents

Preparation method of 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride

The invention relates to the technical field of organic synthesis, in particular to a preparation method of 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride. The preparation method disclosed by the invention comprises the following steps of: (1) preparing benzyl diethanolamine by taking benzyl chloride and diethanolamine as raw materials; (2) preparing benzyl dichloroethylamine hydrochloride by taking benzyl diethanolamine and thionyl chloride as raw materials; and (3) preparing the 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride by taking the benzyl dichloroethylamine hydrochloride and the benzyl cyanide as raw materials. The preparation method disclosed by the invention is simple in process and suitable for industrial production, the HPLC content of the finally obtained 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride is greater than or equal to 98.0%, the total yield (based on diethanolamine) is greater than or equal to 89%, and the 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride has a very good market prospect.

HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES

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Impurities in drugs II: meperidine and its formulations.

Three lots of meperidine hydrochloride, seven lots of meperidine tablets, and 41 lots of meperidine injectables were examined for impurities by TLC. Impurities found were ethyl 1-benzyl-4-phenyl-4-piperidinecarboxylate, methyl-4-piperidinecarboxylate, ethyl-4-phenyl-4-piperidinecarboxylate, and three unidentified compounds. Not all impurities were found in every lot of drug investigated, and none of the impurities exceeded a concentration of 1% of the meperidine present.