71260-16-7

Basic information

• Product Name: 1-(2-METHYLPROPANOYL)-PIPERAZINE
• Synonyms: 1-(2-METHYLPROPANOYL)-PIPERAZINE;1-isobutyrylpiperazine;Piperazine, 1-(2-methyl-1-oxopropyl)- (9CI);1-ISOBUTYRYLPIPERAZINE HYDROCHLORIDE;2-Methyl-1-(piperazin-1-yl)propan-1-one hydrochloride;1-(2-Methylpropanoyl)piperazine, 1-Isobutanoylpiperazine, 1-(2-Methylpropionoyl)piperazine;2-Methyl-1-(piperazin-1-yl)propan-1-one;1-Propanone,2-methyl-1-(1-piperazinyl)-
• CAS NO: 71260-16-7
• Molecular Formula: C₈H₁₆N₂O
• Molecular Weight: 156.23
• EINECS: 200-589-5
• Product Categories: PIPERIDINE;piperazines
• Mol File: 71260-16-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 78 °C
• Flash Point: 122.2 °C
• Appearance: /
• Density: 0.987 g/cm³
• Vapor Pressure: 0.00427mmHg at 25°C
• Refractive Index: 1.465
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.37±0.10(Predicted)
• CAS DataBase Reference: 1-(2-METHYLPROPANOYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-METHYLPROPANOYL)-PIPERAZINE(71260-16-7)
• EPA Substance Registry System: 1-(2-METHYLPROPANOYL)-PIPERAZINE(71260-16-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 71260-16-7(Hazardous Substances Data)

Usage

General Description

1-(2-methylpropanoyl)-piperazine is a chemical compound with the molecular formula C9H18N2O. It is a piperazine derivative, which is a group of organic compounds that contain a six-membered ring with two nitrogen atoms and can have various pharmacological and physiological effects. 1-(2-methylpropanoyl)-piperazine is used as an intermediate in the synthesis of pharmaceuticals and can also be used as a reagent for organic chemistry reactions. It is important to handle this compound with care and in accordance with proper safety procedures due to its potential hazards.

InChI:InChI=1/C8H16N2O/c1-7(2)8(11)10-5-3-9-4-6-10/h7,9H,3-6H2,1-2H3

Upstream product

• 349130-22-9 1-benzyl-4-isobutyrylpiperazine 
• 414910-16-0 tert-butyl 4-formylpiperazine-1-carboxylate 
• 79-30-1 isobutyryl chloride 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 1374567-11-9 C₂₆H₂₈F₃N₅O₄ 
• 1374567-10-8 C₂₅H₂₈ClN₅O₃ 
• 1207453-57-3 methyl 3-(3-(4-isobutyryl piperazine-1-carbonyl)phenyl)-4-oxo-2-(pyridin-4-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate 
• 1207453-14-2 methyl 2,3-bis(3-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate 
• 1207453-13-1 methyl 3-(3-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate 
• 1207453-55-1 9-(3-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8-(pyridin-4-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 
• 1207453-11-9 8,9-bis(3-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 
• 1207453-10-8 9-(3-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 
• 1207453-12-0 3-(4-isobutyrylpiperazine-1-carbonyl)benzaldehyde 
• 1175530-20-7 methyl 3-(4-isobutyrylpiperazine-1-carbonyl)benzoate 

Relevant articles and documents

Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer

Poly (ADP-ribose) polymerase-1 (PARP-1) is a potential target for the discovery of chemosensitizers and anticancer drugs. Amentoflavone (AMF) is reported to be a selective PARP-1 inhibitor. Here, structural modifications and trimming of AMF have led to a series of AMF derivatives (9a-h) and apigenin-piperazine/piperidine hybrids (14a-p, 15a-p, 17a-h, and 19a-f), respectively. Among these compounds, 15l exhibited a potent PARP-1 inhibitory effect (IC50 = 14.7 nM) and possessed high selectivity to PARP-1 over PARP-2 (61.2-fold). Molecular dynamics simulation and the cellular thermal shift assay revealed that 15l directly bound to the PARP-1 structure. In in vitro and in vivo studies, 15l showed a potent chemotherapy sensitizing effect against A549 cells and a selective cytotoxic effect toward SK-OV-3 cells through PARP-1 inhibition. 15l·2HCl also displayed good ADME characteristics, pharmacokinetic parameters, and a desirable safety margin. These findings demonstrated that 15l·2HCl may serve as a lead compound for chemosensitizers and the (BRCA-1)-deficient cancer therapy.

METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)

Provided herein are methods of treating cancer comprising administering a topoisomerase inhibitor, temozolomide, or a platin in combination with a Compound of Formula (I) or Formula (II), where the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein.

Chemical compounds

Formula (1) wherein R represents a halogen atom or a C1-4 alkyl group; R1 represents a C1-4 alkyl group; R2 represents hydrogen or a C1-4 alkyl group; R3 represents hydrogen, or a C1-4 alkyl group; R4 represents a trifluorometyl group; R5 represents hydrogen, a C1-4 alkyl group or C(0)R6; R6? represents C1-4 alkyl, C3-7 cycloalkyl, NH(C1-4 alkyl) or N(C1-4alkyl)2; m is zero or an integer from 1 to 3; n is an integer from 1 to 3 and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation and their use in the treatment of conditions mediated bytachykinins.