713-21-3

Basic information

• Product Name: 2-FLUORO-5-NITROBENZENESULFONYL CHLORIDE
• Synonyms: 2-FLUORO-5-NITROBENZENESULFONYL CHLORIDE;2-Fluoro-5-nitrobenzenesulphonylchloride
• CAS NO: 713-21-3
• Molecular Formula: C6H3ClFNO4S
• Molecular Weight: 239.61
• Mol File: 713-21-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 332.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.685±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-FLUORO-5-NITROBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-NITROBENZENESULFONYL CHLORIDE(713-21-3)
• EPA Substance Registry System: 2-FLUORO-5-NITROBENZENESULFONYL CHLORIDE(713-21-3)

Safety Data

• Hazardous Substances Data: 713-21-3(Hazardous Substances Data)

Usage

General Description

2-Fluoro-5-nitrobenzenesulfonyl chloride, also known as FNBS chloride, is a chemical compound with the formula C6H3ClFNO4S. It is a white to pale yellow crystalline solid that is widely used as a reagent in organic synthesis. FNBS chloride is commonly employed as a protecting group for amines, enabling the selective synthesis of certain chemical compounds. It is also used in the production of pharmaceuticals and agrochemicals. The compound is known for its high reactivity and is handled under careful safety precautions due to its potential health hazards.

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 1219001-36-1 C₆H₃FN₃O₂⁽¹⁺⁾*Cl^(1-) 
• 369-36-8 6-fluoro-3-nitroaniline 

Downstream Products

• 1379071-95-0 N-cyclopropyl-2-fluoro-5-nitrobenzenesulfonamide 
• 1616809-37-0 N-(3-(N-cyclopropylsulfamoyl)-4-fluorophenyl)-3,4-difluorobenzamide 
• 1094887-97-4 5-amino-N-cyclopropyl-2-fluorobenzenesulfonamide 

Relevant articles and documents

Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors

Group I p21-activated kinase (PAK) inhibitors are indicated as important in cancer progression, but achieving high kinase selectivity has been challenging. A bis-anilino pyrimidine PAK1 inhibitor was identified and optimized through structure-based drug design to improve PAK1 potency and achieve high kinase selectivity, giving in vitro probe compound AZ13705339 (18). Reduction of lipophilicity to lower clearance afforded AZ13711265 (14) as an in vivo probe compound with oral exposure in mouse. Such probes will allow further investigation of PAK1 biology.

BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF

The present disclosure provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled compounds, and prodrugs thereof. The provided compounds may be tumor necrosis factor ("TNF") receptor associated protein 1 ("TRAP1") modulators (e.g., TRAP1 activators). The provided compounds may also rescue the activity in PTEN-induced kinase 1 ("PINK1") loss of function contexts. The provided compounds may also improve mitochondrial health, function, quality, quantity, and/or activity, and/or reduce the production of reactive oxygen species. The provided compounds may also refold or solubilize aggregated or misfolded proteins such as α-synuclein. The present disclosure also provides pharmaceutical compositions comprising the provided compounds; kits comprising the provided compounds or pharmaceutical compositions; and methods of using the provided compounds and pharmaceutical compositions (e.g., for treating a disease in a subject in need thereof).

AROMATIC SULFONAMIDE DERIVATIVES

Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.