713124-83-5

Basic information

• Product Name: Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester
• Synonyms: Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester
• CAS NO: 713124-83-5
• Molecular Weight: 499.634
• Mol File: 713124-83-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester(713124-83-5)
• EPA Substance Registry System: Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester(713124-83-5)

Safety Data

• Hazardous Substances Data: 713124-83-5(Hazardous Substances Data)

Upstream product

• 130199-65-4 (1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethan-1-amine 
• 114526-00-0 (2R)-2-[[(benzyloxy)carbonyl](methyl)amino]-3-phenylpropanoic acid 
• 2448-45-5 Cbz-D-Phe 

Downstream Products

• 713124-85-7 ((S)-3-Methyl-1-{methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamoyl}-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 713124-87-9 (S)-2-Amino-4-methyl-pentanoic acid methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-amide 
• 713124-84-6 (R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide 

Relevant articles and documents

Synthesis and X-ray crystal structure of the Dolabella auricularia peptide dolastatin 18

A previously synthesized unit of dolastatin 10 (1), dolaphenine (Doe, 3), was converted in four steps to tripeptide 10. Subsequent condensation with carboxylic acid 11 (four steps from Meldrum's acid) provided a practical synthesis of the cancer cell growth inhibitor dolastatin 18 (2, Dhex-(S)-Leu-(R)-N-Me-Phe-Doe). The synthesis of dolastatin 18 (2) confirmed the R stereochemistry of the N-Me-Phe unit as originally assigned and unusual among amino acid components of the sea hare Dolabella auricularia. An X-ray crystal structure determination of dolastatin 18 was also completed.