7133-56-4

Basic information

• Product Name: 2-hydroxy-N-(2-methylphenyl)benzamide
• Synonyms: 2-hydroxy-N-(2-methylphenyl)benzamide;BENZAMIDE,2-HYDROXY-N-(2-METHYLPHENYL)-
• CAS NO: 7133-56-4
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.26
• Mol File: 7133-56-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 305.6°C at 760 mmHg
• Flash Point: 138.6°C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 0.000449mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 2-hydroxy-N-(2-methylphenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-N-(2-methylphenyl)benzamide(7133-56-4)
• EPA Substance Registry System: 2-hydroxy-N-(2-methylphenyl)benzamide(7133-56-4)

Safety Data

• Hazardous Substances Data: 7133-56-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H13NO2/c1-10-6-2-4-8-12(10)15-14(17)11-7-3-5-9-13(11)16/h2-9,16H,1H3,(H,15,17)

Upstream product

• 95-53-4 o-toluidine 
• 69-72-7 salicylic acid 
• 936-02-7 2-Hydroxybenzoylhydrazine 
• 10025-87-3 trichlorophosphate 
• 1441-87-8 salicyloyl chloride 
• 36930-78-6 C₁₆H₁₅NO₃ 
• 118-55-8 phenyl Salicylate 
• 120041-63-6 2-o-Tolyloxy-benzoyl chloride 
• 6325-68-4 2-(2-methylphenoxy)benzoic acid 
• 119-36-8 methyl salicylate 
• 120041-61-4 N-Phenoxy-2-o-tolyloxy-benzamide 
• 614-68-6 2-tolyl isocyanate 
• 108-95-2 phenol 
• 120041-57-8 N-Methoxy-2-o-tolyloxy-benzamide 

Downstream Products

• 143000-10-6 2-Phenyl-3-o-tolyl-2,3-dihydro-benzo[e][1,3,2]oxazaphosphinin-4-one 
• 73662-23-4 4',5-dichloro-2'-methylsalicylanilide 
• 79402-01-0 3,5-dichloro-2-hydroxy-benzoic acid-(4-chloro-2-methyl-anilide) 
• 634584-59-1 C₅₂H₃₈N₂O₁₀P₂ 
• 143000-19-5 2-Oxo-2-phenyl-3-o-tolyl-2,3-dihydro-2λ⁵-benzo[e][1,3,2]oxazaphosphinin-4-one 
• 7133-62-2 3-o-tolyl-benzo[e][1,3]oxazine-2,4-dione 
• 77067-99-3 4',5-dibromo-2'-methylsalicylanilide 

Relevant articles and documents

Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors

Cancer chemotherapy failure is often due to the overexpression of ATP-binding cassette (ABC) transporters (particularly ABCB1), resulting in a variety of structurally and pharmacologically unrelated drugs efflux. The multidrug resistance (MDR) phenomenon could be reversed by ABCB1 inhibitors. Now, JL-A7 as the lead compound based on a triazol-N-ethyl-tetrahydroisoquinoline scaffold, 18 compounds were designed and synthesized. Substitution in para positions yielded high activities toward ABCB1. Moreover, compound 5 could effectively block the drug efflux function of ABCB1 and increase the accumulation of anti-cancer drugs to achieve effective treatment concentration in MDR cells.

One-pot synthesis of salicylanilides by direct amide bond formation from salicyclic acid under microwave irradiation

A highly efficient protocol for the preparation of aromatic amides is described by the direct reactions between salicyclic acid and aromatic amines in the presence of phosphorous trichloride under microwave irradiation. The method has several advantages over the conventional methods, including operational simplicity, good yield, and reduced reaction time.

Process for preparing aldehyde compounds

The invention relates to a process for the making organic aldehyde compounds from an unsaturated compound by hydroformylation and in the presence of a catalyst system comprising a Group VIII metal and a bidentate phosphorus ligand having two trivalent phosphorus atoms bound to salicylanilide groups.