7142-76-9

Basic information

• Product Name: 9-DIETHYLPHOSPHONOFLUORENE
• Synonyms: 9-DIETHYLPHOSPHONOFLUORENE;9-Diethylphosphonofluorene, 98 %
• CAS NO: 7142-76-9
• Molecular Formula: C₁₇H₁₉O₃P
• Molecular Weight: 302.3
• Mol File: 7142-76-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 443°C at 760 mmHg
• Flash Point: 235.1°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 1.25E-07mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 9-DIETHYLPHOSPHONOFLUORENE(CAS DataBase Reference)
• NIST Chemistry Reference: 9-DIETHYLPHOSPHONOFLUORENE(7142-76-9)
• EPA Substance Registry System: 9-DIETHYLPHOSPHONOFLUORENE(7142-76-9)

Safety Data

• Hazardous Substances Data: 7142-76-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H19O3P/c1-3-19-21(18,20-4-2)17-15-11-7-5-9-13(15)14-10-6-8-12-16(14)17/h5-12,17H,3-4H2,1-2H3

Upstream product

• 762-04-9 phosphonic acid diethyl ester 
• 832-80-4 9-diazofluorenone 
• 119-61-9 benzophenone 
• 34881-13-5 diethyl (9-Hydroxy-9H-fluorene-9-yl)phosphonate 
• 1940-57-4 9H-fluoren-9-yl bromide 
• 122-52-1 triethyl phosphite 

Downstream Products

• 87682-45-9 diethyl 3-(fluoren-9-ylidene)-1,3-diphenylpropen-1-yl phosphate 
• 486-25-9 9-fluorenone 
• 87682-42-6 9-(1,3-diphenylprop-2-yn-1-ylidene)-9H-fluorene 

Relevant articles and documents

Lewis Acid Enables Ketone Phosphorylation to Form a C-P Bond and a C-C Bond: Synthesis of 9-Phosphoryl Fluorene Derivatives

An efficient method for the Lewis acid promotion of the synthesis 9-phosphoryl fluorenes has been reported. This method focuses on ketone phosphonylation to form a C-P bond and a C-C bond between diphenylmethanone and H-phosphinate esters, H-phosphites, and H-phosphine oxides via phospha-aldol elimination, in which a series of 9-phosphoryl fluorene derivatives were selectively obtained in moderate to excellent yields.

Benzylphosphonic acid inhibitors of human prostatic acid phosphatase

A series of α-substituted benzylphosphonic acids is described as inhibitors of human prostatic acid phosphatase, an enzyme has been used as a model to study aryl phosphatases. The most potent inhibitors in this series are 2-trifluoromethylbenzhydrylphosphonic acid (9 μM), and α-(2-phenylethyl)benzylphosphonic acid (14 μM). The structure-activity studies suggest that bulk tolerance beyond the phosphate binding area limits the steric or hydrophobic contribution to inhibitor potency achieved through α-carbon substitution.

Anomaly in Palladium-Catalyzed Phenylethynylation of 2,2'-Dihalobiphenyls: Formation of Alkylidenefluorenes

2,2'-Diiodobiphenyl and 5,5'-dinitro-2,2'-dihalobiphenyls underwent palladium-catalyzed phenylethynylation with 2 mol of phenylacetylene to yield 3-(fluoren-9-ylidene)-1,3-diphenylpropyne and 3-(3,6-dinitrofluoren-9-ylidene)-1,3-diphenylpropyne, respectively.These fluorenyl compounds exhibited well-defined splitting patterns for the fluorenyl ring protons in the 250-MHz proton NMR spectra.The structure of 3-(fluoren-9-ylidene)-1,3-diphenylpropyne was further confirmed by an independent synthesis via the thermolysis of diethyl 3-(fluoren-9-ylidene)-1,3-diphenylpropen-1-yl phosphate.The mechanistic importance of the complex iodo(fluoren-9-ylidenebenzyl)bis(triphenylphosphine)palladium(II) in the catalytic cycle was established on the basis of its reaction with phenylacetylene to give 3-(fluoren-9-ylidene)-1,3-diphenylpropyne.