7144-05-0

Basic information

• Product Name: 4-(Aminomethyl)piperidine
• Synonyms: 4-(Amionomethyl)piperidine;4-piperidinemethanamine;4-Piperidinylmethanamine;Piperidine, 4-(aminomethyl)-;TIMTEC-BB SBB004305;C-PIPERIDIN-4-YL-METHYLAMINE;LABOTEST-BB LTBB000691;4-(AMINOMETHYL)-1-PIPERIDINE
• CAS NO: 7144-05-0
• Molecular Formula: C₆H₁₄N₂
• Molecular Weight: 114.19
• EINECS: 230-446-3
• Product Categories: Piperidine;Amines;API intermediates;Organic Storage;Alternative Energy;Building Blocks;C5 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Materials for Hydrogen Storage;Materials Science;Piperidines
• Mol File: 7144-05-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 25 °C(lit.)
• Boiling Point: 200 °C(lit.)
• Flash Point: 174 °F
• Appearance: Clear colorless to slightly yellow/Liquid After Melting
• Density: 0.9151 (rough estimate)
• Vapor Pressure: 0.331mmHg at 25°C
• Refractive Index: n20/D 1.49(lit.)
• Storage Temp.: 2-8°C
• PKA: 10.53±0.10(Predicted)
• Water Solubility: Soluble
• Sensitive: Air Sensitive
• BRN: 471185
• CAS DataBase Reference: 4-(Aminomethyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Aminomethyl)piperidine(7144-05-0)
• EPA Substance Registry System: 4-(Aminomethyl)piperidine(7144-05-0)

Safety Data

• Hazard Codes: C
• Statements: 34-20/21/22
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3259 8/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 7144-05-0(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to slightly yellow liquid

Uses

Different sources of media describe the Uses of 7144-05-0 differently. You can refer to the following data:
1. Reactant:? ;Evaulated as a small molecule inhibitor of CD4-gp120 binding1Reagent? ;Involved in solvothermal preparation of germanium oxide hydroxide 3D net zeotype2? ;Involved in zeolite synthesis3,4Coupling agent for adhesive systems5
2. Reactant: Evaulated as a small molecule inhibitor of CD4-gp120 binding Reagent Involved in solvothermal preparation of germanium oxide hydroxide 3D net zeotype Involved in zeolite synthesis Coupling agent for adhesive systems
3. 4-(Aminomethyl)piperidine (4-AMP) can be used in the synthesis of Schiff bases. It is a trifunctional amine for the preparation of linear poly(amido amine)s, which form micelles for controlled delivery of drugs. 4-AMP can also be used as a linker for the synthesis of dendron-OMS hybrids.

General Description

This product has been enhanced for energy efficiency.

InChI:InChI=1/C6H14N2/c7-5-6-1-3-8-4-2-6/h6,8H,1-5,7H2/p+2

Upstream product

• 39546-32-2 4-carboxamidopiperidine 
• 498-94-2 isonipecotic acid 
• 773-64-8 2-mesitylenesulphonyl chloride 
• 110-60-1 1,4-diaminobutane 
• 132431-14-2 4-(Benzyloxycarbonylamino-methyl)-piperidine-1-carboxylic acid benzyl ester 
• 4395-98-6 4-cyanopiperidine 

Downstream Products

• 727719-96-2 N-phenylacetyl-4-aminomethylpiperidine 
• 727720-12-9 N-phenylacetyl-4-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]methylpiperidine 
• 727719-97-3 N-(phenylacetyl)-4-[(6-(tert-butoxycarbonylamino)hexanoylamidomethyl)]piperidine 
• 144222-22-0 tert-butyl 4-(aminomethyl)piperidine-1-carboxylate 
• 165288-17-5 N,N'-bis(mesitylsulfonyl)-4-(aminomethyl)piperidine 
• 111436-12-5 3-(4-chloroanilino)-10-(4-chlorophenyl)-2,10-dihydro-2-<(4-piperidinylmethyl)imino>phenazine 
• 132431-14-2 4-(Benzyloxycarbonylamino-methyl)-piperidine-1-carboxylic acid benzyl ester 
• 71207-29-9 N-hexahydro-4-pyridinylmethyl-N-phenylmethylidenamine 
• 71207-29-9 N-benzylidene-1-(4-piperidyl)methylamine 
• 80254-14-4 Trifluoro-methanesulfonate2,4,6-triphenyl-1-piperidin-4-ylmethyl-pyridinium; 
• 98064-09-6 2,2'-dithiobis dihydrochloride 
• 170353-28-3 (1-(pyridin-2-yl)piperidin-4-yl)methanamine 
• 258345-24-3 (1-iso-butyl-4-piperidyl)methylamine 
• 65017-57-4 1-(1-butyl-4-piperidinyl)methanamine 

Relevant articles and documents

Spectrophotometric and thermal studies on the charge - Transfer complexes of 4-(aminomethyl) piperidine as donor with σ- And π-electron acceptors

The spectroscopic characteristics of the solid charge-transfer molecular complexes (CT) formed in the reaction of the electron donor 4-(aminomethyl) piperidine (4AMP) with the σ-acceptor iodine and the π-acceptors 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4,4,6-tetrabromo-2,5- cyclohexadienone (TBCHD) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) have been studied in chloroform at 25 C. These were investigated through electronic, infrared spectra and thermal analysis as well as elemental analysis. The results show that the formed solid CT-complexes have the formulas [ (4AMP)I]+I3-, [(4AMP)(DDQ)2] and [(4AMP)(TBCHD)] while in the case of 4AMP-TCNQ reaction, a short-lived CT complex is formed followed by rapid N-substitution by TCNQ forming the final reaction product 7,7,8-tricyano-8-aminomethylpiperidinylquinodimethane [TCAMPQDM] in full agreement with the known reaction stoichiometries in solution as well as the elemental measurements and the thermal analysis confirmed the structure of the obtained compounds. The formation constant kCT, molar extinction coefficient εCT, free energy change ΔG0 and CT energy ECT have been calculated for the CT-complexes [ (4AMP)I]+I3-, [(4AMP)(DDQ)2] and [(4AMP)(TBCHD)].

Electrophilic Zinc Homoenolates: Synthesis of Cyclopropylamines from Cyclopropanols and Amines

Metal homoenolates, produced via C-C bond cleavage of cyclopropanols, have been extensively investigated as nucleophiles for the synthesis of β-substituted carbonyl derivatives. Herein, we demonstrate that zinc homoenolates can react as carbonyl-electrophiles in the presence of nucleophilic amines to yield highly valuable trans-cyclopropylamines in good yields and high diastereoselectivities. GSK2879552, a lysine demethylase 1 inhibitor currently in clinical trials for the treatment of small cell lung carcinoma, was synthesized using this strategy.

ANALOGS OF BIOLOGICALLY ACTIVE, NATURALLY OCCURRING POLYAMINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT

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