7145-61-1

Basic information

• Product Name: 3-Chloro-6-(methylthio)pyridazine
• Synonyms: 3-Chloro-6-(methylthio)pyridazine;3-Chloro-6-Methylsulfanylpyridazine
• CAS NO: 7145-61-1
• Molecular Formula: C₅H₅ClN₂S
• Molecular Weight: 160.62
• Mol File: 7145-61-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 323.2 °C at 760 mmHg
• Flash Point: 149.3 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 0.000502mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: 3-Chloro-6-(methylthio)pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-6-(methylthio)pyridazine(7145-61-1)
• EPA Substance Registry System: 3-Chloro-6-(methylthio)pyridazine(7145-61-1)

Safety Data

• Hazardous Substances Data: 7145-61-1(Hazardous Substances Data)

Usage

General Description

3-Chloro-6-(methylthio)pyridazine is a chemical compound with the molecular formula C5H4ClN2S. It is a chlorinated pyridazine derivative with a methylthio group attached to the sixth position of the pyridazine ring. 3-Chloro-6-(methylthio)pyridazine is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also utilized in organic synthesis and as a reagent in chemical research. 3-Chloro-6-(methylthio)pyridazine is known for its mild, efficient, and selective reactivity, making it a valuable compound in the development of new chemical processes and products. However, it should be handled with care due to its potential hazards and toxicity.

InChI:InChI=1/C5H5ClN2S/c1-9-5-3-2-4(6)7-8-5/h2-3H,1H3

Upstream product

• 3916-78-7 6-chloro-3(2H)-pyridazinethione 
• 74-88-4 methyl iodide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 3916-78-7 3-mercapto-6-chloropyridazine 
• 141-30-0 3,6-dichlorpyridazine 
• 5188-07-8 sodium thiomethoxide 
• 74-93-1 methylthiol 
• 40954-07-2 6-Chloro-3-methylthiopyridazine-1-oxide 

Downstream Products

• 59019-09-9 3-methylsulfanyl-6-phenoxy-pyridazine 
• 7145-62-2 3-chloro-6-(methylsulfonyl)pyridazine 
• 100224-59-7 3-[3,6-dihydro-4-(3-methylphenyl)-1(2 H)-pyridinyl]-6-(methylthio)pyridazine 

Relevant articles and documents

Synthesis of novel 3-allylseleno-6-alkylthiopyridazines: Their anticancer activity against MCF-7 cells

A new series of 3-allylseleno-6-alkylthiopyridazines 6a-6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine) showed higher potency than 5FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 6e.

Tetrazine-mediated bioorthogonal prodrug-prodrug activation

The selective and biocompatible activation of prodrugs within complex biological systems remains a key challenge in medical chemistry and chemical biology. Herein we report, for the first time, a dual prodrug activation strategy that fully satisfies the principle of bioorthogonality by the symbiotic formation of two active drugs. This dual and traceless prodrug activation strategy takes advantage of the INVDA chemistry of tetrazines (here a prodrug), generating a pyridazine-based miR21 inhibitor and the anti-cancer drug camptothecin and offers a new concept in prodrug activation.

OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH

The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.