7150-63-2Relevant articles and documents
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy
Bulic, Bruno,Pickhardt, Marcus,Khlistunova, Inna,Biernat, Jacek,Mandelkow, Eva-Maria,Mandelkow, Eckhard,Waldmann, Herbert
, p. 9215 - 9219 (2008/12/22)
Breaking up the crowd: The pathological aggregation of tau protein correlates closely with the progression of Alzheimer's disease. Rhodanine-based inhibitors of tau aggregation (e.g. 1) have been identified, and it has been shown that tau aggregation in a
A convenient synthesis of symmetrical N,N′-dialkylureas by the reactions of 4-chloro-5H-1,2,3-dithiazol-5-one with alkylamines
Chang, Yong-Goo,Lee, Hyi-Seung,Kim, Kyongtae
, p. 8197 - 8200 (2007/10/03)
Treatment of 4-chloro-5H-1,2,3-dithiazol-5-one with primary and secondary alkylamines (>2 equiv.) in CH2Cl2 at rt afforded symmetrical N,N′-disubstituted ureas in moderate to good yields. Similarly, the reactions with amino acid ester hydrochlorides in the presence of Et3N (>3 equiv.) under the same conditions gave symmetrical ureas.
An approach to the design of molecular solids. Strategies for controlling the assembly of molecules into two-dimensional layered structures
Chang, Yuh-Loo,West, Mary-Ann,Fowler, Frank W.,Lauher, Joseph W.
, p. 5991 - 6000 (2007/10/02)
A design strategy for the synthesis of molecular crystals containing two-dimensional layers is formulated and demonstrated by the synthesis and structure determination of a series of dicarboxylic acid urea derivatives. The design strategy is based upon th