71690-05-6

Basic information

• Product Name: 2,3-DICHLORO-5-FORMYLPYRIDINE
• Synonyms: 2,3-DICHLORO-5-FORMYLPYRIDINE;5,6-DICHLOROPYRIDINE-3-CARBALDEHYDE;5,6-Dichloropyridine-3-carboxaldehyde;5,6-Dichloro-3-pyridinecarboxaldehyde;5,6-Dichloropyridyl-3-carboxaldehyde
• CAS NO: 71690-05-6
• Molecular Formula: C₆H₃Cl₂NO
• Molecular Weight: 176
• Product Categories: Pyridine;Boronic Acid;Heterocycle-Pyridine series
• Mol File: 71690-05-6.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 268.604 °C at 760 mmHg
• Flash Point: 116.248 °C
• Appearance: /
• Density: 1.489 g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2,3-DICHLORO-5-FORMYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DICHLORO-5-FORMYLPYRIDINE(71690-05-6)
• EPA Substance Registry System: 2,3-DICHLORO-5-FORMYLPYRIDINE(71690-05-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 71690-05-6(Hazardous Substances Data)

Usage

Uses

5,6-Dichloropyridyl-3-carboxaldehyde is used to prepare [(pyridyl)piperazinyl]benzimidazoles analogs as potent, orally available antagonists of the transient receptor potential vanilloid 1 and analgesics. It is also used to synthesize heterocyclic aryl isoxazolines with insecticidal activities.

InChI:InChI=1/C6H3Cl2NO/c7-5-1-4(3-10)2-9-6(5)8/h1-3H

Upstream product

• 162327-73-3 5,6-dichloro-N-methoxy-N-methyl-3-pyridinecarboxamide 
• 54127-30-9 5,6-dichloro-3-pyridinemethanol 
• 41667-95-2 5,6-dichloronicotinic acid 
• 54127-29-6 5,6-dichloronicotinoyl chloride 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1073616-37-1 (S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide 
• 1073616-26-8 (S)-3-chloro-5-(1,2-dihydroxyethyl)-3',6'-dihydro-2'H-[2,4']bipyridinyl-1'-carboxylic acid (3-chloro-4-trifluoromethylphenyl)amide 
• 1073616-33-7 (S)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)-N-(4-trifluoromethoxyphenyl)piperazine-1-carboxamide 
• 1073616-35-9 (S)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)piperazine-1-carboxamide 
• 1073616-38-2 4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide 
• 1073616-41-7 3-chloro-5-(methylsulfonamidomethyl)-N-[4-(trifluoromethyl)phenyl]-3',6'-dihydro-(2,4'-bipyridine)-1'(2'H)-carboxamide 
• 1073616-32-6 (S)-N-(4-tert-butylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide 
• 71690-06-7 2,3-dichloro-5-(difluoromethyl)pyridine 
• 1073617-14-7 (R)-3-chloro-5-(1,2-dihydroxyethyl)-N-[4-(trifluoromethyl)phenyl]-3',6'-dihydro-(2,4'-bipyridine)-1'(2'H)-carboxamide 
• 1073616-24-6 (S)-3-chloro-5-(1,2-dihydroxyethyl)-N-[4-(trifluoromethyl)phenyl]-3',6'-dihydro-(2,4'-bipyridine)-1'(2'H)-carboxamide 
• 943137-86-8 3-(5-chloro-6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole 
• 950482-85-6 5-(3,5-dichlorophenyl)-3-(5,6-dichloro-3-pyridyl)-5-trifluoromethyl-4,5-dihydroisoxazole 
• 1308279-71-1 ethyl (E)-3-{2-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chloro-5-pyridinyl}-2-propenoate 
• 1308279-77-7 ethyl (E)-3-{2-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-chloro-5-pyridinyl}-2-propenoate 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIDINE COMPOUNDS AND INTERMEDIATES THEREOF

The present invention discloses a process for the preparation of substituted pyridine compounds of formula (I), comprises a step in which vinylogous nitriles of formula (II), are obtained from substituted α,β-unsaturated nitrile compounds of formula (III), and a further step of converting the vinylogous nitrile compounds of formula (II) into substituted pyridines of formula (I); wherein R1, R2, R3, R4 and LG are as defined in the description.

Method for preparing aldehyde and acid by electrochemical dehydrochlorination of polychloromethylpyridine derivatives

The invention discloses a method for preparing aldehyde and an acid by electrochemical dechlorination of a polychloromethylpyridine derivative, the method comprises the following steps: dissolving thepolychloromethylpyridine derivative in an acetic acid and acetate- containing buffer solution to obtain an electrolytic reaction solution; taking the electrolytic reaction solution as a cathode liquid, performing electrolytic reduction dechlorination reaction at a cathode, and hydrolyzing in the solution to obtain a polychlorinated pyridylaldehyde or acid derivative. The polychloromethylpyridinederivative is shown in formula (I), and the product polychlorinated pyridylaldehyde or acid derivative is shown in formula (II): in the formula (I), m is 0, 1, 2, 3 or 4, n is 0 or 1, and R' is an easy-to-oxidize or easy-to-hydrolyze substituent. The m and the R' in the formula (II) are same as that in the formula (I), R is H or OH, no waste acid is generated in the preparation process, the easy-to-oxidize or easy-to-hydrolyze substituent contained in the polychloromethylpyridine derivative and carbon-chlorine bonds on pyridine rings are not affected, and the recovery conversion rate is high.

Heterocyclic compounds

The invention relates to compounds of Formula I: wherein Ar1, Ar2, Ar3, L1, L2, Y, Z and v are defined in the specification, and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof.