7173-51-5Relevant articles and documents
Supramolecular effects on the antifungal activity of cyclodextrin/di-n- decyldimethylammonium chloride mixtures
Leclercq, Lo?c,Lubart, Quentin,Dewilde, Anny,Aubry, Jean-Marie,Nardello-Rataj, Véronique
, p. 336 - 345 (2012)
Candidiasis infections are growing problem worldwide especially for the immunocompromised individuals. Di-n-decyldimethylammonium chloride is one of the most common antifungal agents used to clean medical devices. The current study examines the antifungal mechanism of di-n-decyldimethylammonium cation and its cyclodextrin inclusion complexes. Depending on the type of cyclodextrin (α-, β- or γ-CD), inclusion complexes can be as active as ammonium alone in terms of microorganism death (fungicidal activity). Moreover, with β-CD inclusion complexes, synergism is observed against fungus growth (fungistatic activity). Based on molecular dynamics, we propose a mechanism supported by cell number, selective electrode and ζ-potential measurements as a function of time. The mechanism involves four steps: (i) the positively-charged complex diffuses through the solution, (ii) it adsorbs onto the fungus membrane surface by electrostatic interaction, (iii) then it dissociates and the ammonium inserts in the microorganism membrane, and (iv) the change of the cell surface charge induces cell lysis.
Supramolecular assistance between cyclodextrins and didecyldimethylammonium chloride against enveloped viruses: Toward eco-biocidal formulations
Leclercq, Lo?c,Dewilde, Anny,Aubry, Jean-Marie,Nardello-Rataj, Véronique
, p. 273 - 281 (2016/09/07)
Nosocomial infections have emerged as important causes of morbidity and mortality in immunocompromised individuals. In this respect, biocides are widely used in hospitals leading to resistant microorganisms. We show here that cyclodextrins can remarkably boost the virucidal activity of di-n-decyldimethylammonium chloride. These oligosaccharides synergistically work with the biocide affording a noticeable reduction of the active virucide concentration between 40 and 85%. Partial replacement of a significant amount of the biocide by eco- and bio-compatible cyclodextrins whilst maintaining the same activity is of great interest as it allows the reduction of the toxicological drawbacks of classical biocide mixtures.
Modeling of multiple equilibria in the self-aggregation of di- n -decyldimethylammonium chloride/octaethylene glycol monododecyl ether/cyclodextrin ternary systems
Leclercq, Loic,Lubart, Quentin,Aubry, Jean-Marie,Nardello-Rataj, Veronique
, p. 6242 - 6252 (2013/07/27)
The surface tension equations of binary surfactant mixtures (di-n-decyldimethylammonium chloride and octaethylene glycol monododecyl ether) are established by combining the Szyszkowski equation of surfactant solutions, the ideal or nonideal mixing theory, and the phase separation model. For surfactant mixtures, the surface tension at the air-water interface is calculated using nonideal theory due to synergism between the two adsorbed surfactant types. The incorporation of cyclodextrin complexation model to the surface tension equations gives a robust model for the description of the surface tension isotherms of binary, ternary, and more complex systems involving numerous inclusion complexes. The surface tension data obtained experimentally shows excellent agreement with the theoretical model below and above the formation of micelles. The strong synergistic effect observed between the two surfactants is disrupted by the presence of CDs, leading to ideal behavior of ternary systems. Indeed, depending on the nature of the cyclodextrin (i.e., α, β, or γ), which allows a tuning of the cavity size, the binding constants with the surfactants are modified as well as the surface properties due to strong modification of equilibria involved in the ternary mixture.
