7177-50-6 Usage
Description
Nafcillin sodium salt monohydrate is a semi-synthetic antibiotic derived from the penicillin group. It is a white to off-white crystalline powder with a characteristic odor. Nafcillin sodium salt monohydrate exhibits potent antibacterial properties, particularly against gram-positive bacteria, and is effective in inhibiting bacterial transpeptidase enzymes. Nafcillin sodium salt monohydrate is also notable for its resistance to beta-lactamase, an enzyme that can render certain antibiotics ineffective.
Uses
Used in Pharmaceutical Industry:
Nafcillin sodium salt monohydrate is used as an antibiotic for the treatment of infections caused by gram-positive bacteria. Its application is primarily due to its effectiveness in combating a wide range of gram-positive bacterial infections, including those caused by Staphylococcus and Streptococcus species.
Used as a Bacterial Transpeptidase Inhibitor:
In the medical field, Nafcillin sodium salt monohydrate is utilized as a bacterial transpeptidase inhibitor. This function is crucial in disrupting the synthesis of bacterial cell walls, thereby inhibiting bacterial growth and contributing to the treatment of various infections.
Used in Antimicrobial Applications:
Nafcillin sodium salt monohydrate is employed as an antimicrobial agent, particularly in the treatment of skin and soft tissue infections, as well as in the prophylaxis of surgical site infections. Its use in these applications is attributed to its ability to target and eliminate gram-positive bacteria, which are common culprits in such infections.
Used in Beta-Lactamase Resistant Formulations:
In the pharmaceutical industry, Nafcillin sodium salt monohydrate is used in the development of antibiotics that are resistant to beta-lactamase, an enzyme produced by some bacteria to inactivate certain penicillin-based drugs. This resistance enhances the drug's effectiveness against a broader spectrum of bacterial infections, particularly those caused by beta-lactamase-producing strains.
Therapeutic Function
Antibacterial
Clinical Use
Nafcillin sodium, 6-(2-ethoxy-1-naphthyl)penicillin sodium(Unipen), is another semisynthetic penicillin that resultedfrom the search for penicillinase-resistant compounds. Likemethicillin, nafcillin has substituents in positions ortho tothe point of attachment of the aromatic ring to the carboxamidegroup of penicillin. No doubt, the ethoxy group andthe second ring of the naphthalene group play steric roles instabilizing nafcillin against penicillinase. Very similar structureshave been reported to produce similar results in somesubstituted 2-biphenylpenicillins. Unlike methicillin, nafcillin is stable enough in acid topermit its use by oral administration. When it is givenorally, its absorption is somewhat slow and incomplete,but satisfactory plasma levels may be achieved in about1 hour. Relatively small amounts are excreted throughthe kidneys; most is excreted in the bile. Even thoughsome cyclic reabsorption from the gut may occur, nafcillingiven orally should be readministered every 4 to 6 hours.This salt is readily soluble in water and may be administeredintramuscularly or intravenously to obtain highplasma concentrations quickly for the treatment of seriousinfections.Nafcillin sodium may be used in infections causedsolely by penicillin G-resistant staphylococci or whenstreptococci are present also. Although it is recommendedthat it be used exclusively for such resistant infections, nafcillin is also effective against pneumococci and groupA -hemolytic streptococci. Because, like other penicillins,it may cause allergic side effects, it should be administeredwith care.
Check Digit Verification of cas no
The CAS Registry Mumber 7177-50-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,7 and 7 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 7177-50:
(6*7)+(5*1)+(4*7)+(3*7)+(2*5)+(1*0)=106
106 % 10 = 6
So 7177-50-6 is a valid CAS Registry Number.
InChI:InChI=1/C21H22N2O5S.Na.H2O/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23;;/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27);;1H2/q;+1;/p-1/t15-,16+,19-;;/m1../s1
