71845-20-0

Basic information

• Product Name: [4-(2-PHENYLETHYL)PHENYL]AMINEHYDROCHLORIDE
• Synonyms: 4-phenethylaniline hydrochloride;[4-(2-PHENYLETHYL)PHENYL]AMINEHYDROCHLORIDE
• CAS NO: 71845-20-0
• Molecular Formula: C₁₄H₁₅N*ClH
• Molecular Weight: 233.74
• Mol File: 71845-20-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 320.1°Cat760mmHg
• Flash Point: 153.9°C
• Appearance: /
• Density: 1.065g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: [4-(2-PHENYLETHYL)PHENYL]AMINEHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(2-PHENYLETHYL)PHENYL]AMINEHYDROCHLORIDE(71845-20-0)
• EPA Substance Registry System: [4-(2-PHENYLETHYL)PHENYL]AMINEHYDROCHLORIDE(71845-20-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 71845-20-0(Hazardous Substances Data)

Usage

General Description

[4-(2-Phenylethyl)phenyl]aminehydrochloride is a chemical compound that consists of a phenyl ring attached to a 2-phenylethyl group and an amine group. It is in the form of a hydrochloride salt. [4-(2-PHENYLETHYL)PHENYL]AMINEHYDROCHLORIDE may be used in the synthesis of various organic molecules and pharmaceuticals due to its unique structure and chemical properties. The presence of the amine group makes it potentially useful in medicinal chemistry, as it can potentially interact with biological systems and be used as a building block in the synthesis of drugs or other bioactive compounds. Additionally, the phenyl ring and 2-phenylethyl group confer aromatic and hydrophobic properties that may be relevant in certain chemical and biological applications.

Upstream product

• 1694-20-8 trans-4-nitrostilbene 
• 1694-20-8 4-nitrostilbene 

Downstream Products

• 1263998-59-9 5-(2-phenylethyl)isatin 
• 91459-41-5 5-(2-phenylethyl)-1H-indole 

Relevant articles and documents

Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues

Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform with (E)-5-styrylisatin being the most potent inhibitor. To further investigate these structure-activity relationships (SAR), in the present study, additional C5- and C6-substituted isatin analogues were synthesized and evaluated as inhibitors of recombinant human MAO-A and MAO-B. With the exception of 5-phenylisatin, all of the analogues examined were selective MAO-B inhibitors. The C5-substituted isatins exhibited higher binding affinities to MAO-B than the corresponding C6-substituted homologues. The most potent MAO-B inhibitor, 5-(4-phenylbutyl) isatin, exhibited an IC50 value of 0.66 nM, approximately 13-fold more potent than (E)-5-styrylisatin and 18,500-fold more potent than isatin. The most potent MAO-A inhibitor was found to be 5-phenylisatin with an IC 50 value of 562 nM. The results document that substitution at C5 with a variety of substituents is a general strategy for enhancing the MAO-B inhibition potency of isatin. Possible binding orientations of selected isatin analogues within the active site cavities of MAO-A and MAO-B are proposed.