718630-59-2 Usage
Description
3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide, also known as PHA-793887, is a potent cyclin-dependent kinase (CDK) inhibitor. It has a complex chemical structure with a tetrahydro-dimethyl-pyrrolo-pyrazol backbone and a butanamide group. PHA-793887 has shown promising therapeutic activity against various types of cancer.
Uses
Used in Oncology:
PHA-793887 is used as a CDK inhibitor for the treatment of acute leukemias. It has demonstrated promising therapeutic activity in both in vitro and in vivo studies. 3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide modulates E2F transcriptional factor-dependent cell cycle, DNA replication, mitosis, and apoptosis-related genes in tumors, leading to the inhibition of cancer cell growth and proliferation.
Used in Solid Tumor Treatment:
PHA-793887 is also used in the treatment of solid tumors. It has been shown to modulate E2F transcriptional factor-dependent genes in both tumors and skin biopsies from patients with solid tumors. This suggests that PHA-793887 may have potential applications in the treatment of various solid malignancies, including those of the breast, lung, pancreas, colon, and ovaries.
Check Digit Verification of cas no
The CAS Registry Mumber 718630-59-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,1,8,6,3 and 0 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 718630-59:
(8*7)+(7*1)+(6*8)+(5*6)+(4*3)+(3*0)+(2*5)+(1*9)=172
172 % 10 = 2
So 718630-59-2 is a valid CAS Registry Number.
