719-70-0

Basic information

• Product Name: 1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE
• Synonyms: 1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE;BUTTPARK 45\09-69;N-(4-FLUORO-2-NITRO-PHENYL)-PIPERIDINE
• CAS NO: 719-70-0
• Molecular Formula: C₁₁H₁₃FN₂O₂
• Molecular Weight: 224.23
• Product Categories: Amines;blocks;FluoroCompounds;NitroCompounds;Piperidine
• Mol File: 719-70-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 353.2°C at 760 mmHg
• Flash Point: 167.4°C
• Appearance: /Solid
• Density: 1.261g/cm³
• Vapor Pressure: 3.64E-05mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE(719-70-0)
• EPA Substance Registry System: 1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE(719-70-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 719-70-0(Hazardous Substances Data)

Usage

General Description

1-(4-Fluoro-2-nitrophenyl)piperidine is a specialized chemical compound. The term 'Fluoro' in its name indicates the presence of the element Fluorine, while 'Nitrophenyl' suggests the presence of a nitro group attached to a phenyl group. The Piperidine refers to a heterocyclic organic compound implying a ring structure in its molecular formation. The presence of fluorine contributes to its chemical stability, while the nitro group contributes to its reactivity, particularly in reduction reactions. The detailed properties such as toxicity, stability, reactive characteristics, and applications of this compound would need to be evaluated through specialized chemical analysis.

InChI:InChI=1/C11H13FN2O2/c12-9-4-5-10(11(8-9)14(15)16)13-6-2-1-3-7-13/h4-5,8H,1-3,6-7H2

Upstream product

• 110-89-4 piperidine 
• 364-74-9 1,4-difluoro-2-nitrobenzene 

Downstream Products

• 252758-87-5 5-fluoro-2-(piperidin-1-yl)aniline 

Relevant articles and documents

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Malaria is a devastating parasitic disease caused by parasites from the genus Plasmodium. Therapeutic resistance has been reported against all clinically available antimalarials, threatening our ability to control the disease and therefore there is an ongoing need for the development of novel antimalarials. Towards this goal, we identified the 2-(N-phenyl carboxamide) triazolopyrimidine class from a high throughput screen of the Janssen Jumpstarter library against the asexual stages of the P. falciparum parasite. Here we describe the structure activity relationship of the identified class and the optimisation of asexual stage activity while maintaining selectivity against the human HepG2 cell line. The most potent analogues from this study were shown to exhibit equipotent activity against P. falciparum multidrug resistant strains and P. knowlesi asexual parasites. Asexual stage phenotyping studies determined the triazolopyrimidine class arrests parasites at the trophozoite stage, but it is likely these parasites are still metabolically active until the second asexual cycle, and thus have a moderate to slow onset of action. Non-NADPH dependent degradation of the central carboxamide and low aqueous solubility was observed in in vitro ADME profiling. A significant challenge remains to correct these liabilities for further advancement of the 2-(N-phenyl carboxamide) triazolopyrimidine scaffold as a potential moderate to slow acting partner in a curative or prophylactic antimalarial treatment.

METHOD OF REGULATING PHOSPHORYLATION OF SR PROTEIN AND ANTIVIRAL AGENTS COMPRISING SR PROTEIN ACTIVITY REGULATOR AS THE ACTIVE INGREDIENT

The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhi