72115-06-1

Basic information

• Product Name: 4-amino-2-methylbenzonitrile
• Synonyms: 4-amino-2-methylbenzonitrile
• CAS NO: 72115-06-1
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16492
• Mol File: 72115-06-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 298.801 °C at 760 mmHg
• Flash Point: 134.511 °C
• Appearance: /
• Density: 1.105 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 4-amino-2-methylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-2-methylbenzonitrile(72115-06-1)
• EPA Substance Registry System: 4-amino-2-methylbenzonitrile(72115-06-1)

Safety Data

• Hazardous Substances Data: 72115-06-1(Hazardous Substances Data)

Usage

General Description

4-Amino-2-methylbenzonitrile is a chemical compound with the formula C8H8N2. It is a pale yellow solid that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. 4-Amino-2-methylbenzonitrile is primarily used in the production of antihypertensive drugs such as Olmesartan medoxomil. Additionally, 4-Amino-2-methylbenzonitrile is also used in the manufacture of fluorescent dyes and pigments. Due to its versatile applications, this chemical has garnered significant interest in the chemical and pharmaceutical industries for its potential in drug development and manufacturing. However, it is important to handle this compound with care as it can be toxic if ingested or inhaled. Proper safety measures and handling procedures should be followed when working with 4-Amino-2-methylbenzonitrile.

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 7149-70-4 2-bromo-5-nitrotoluene 
• 6933-10-4 amino-5-bromo-2-toluene 
• 96784-54-2 3-methyl-4-nitrobenzonitrile 
• 7647-01-0 hydrogenchloride 
• 89001-53-6 2-cyano-5-nitrotoluene 
• 67832-11-5 4-bromo-2-methylbenzonitrile 
• 1338209-70-3 N-(4-cyano-3-methylphenyl)-2-methylpropane-2-sulfinamide 

Downstream Products

• 2486-75-1 4-amino-2-methylbenzoic acid 
• 1572509-96-6 C₂₀H₂₁N₃O₃S 
• 1422284-89-6 N-(4-cyano-3-methylphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide 
• 947494-51-1 (2R)-3-bromo-N-(4-cyano-3-methylphenyl)-2-hydroxy-2-methylpropionamide 
• 52771-13-8 4-amino-2-methylbenzamide 
• 52107-73-0 4-Iod-2-methylbenzophenon 
• 52164-27-9 2-methyl-4-iodoacetophenone 

Relevant articles and documents

A [...] intermediate 2 - methyl - 4 - N - (2 - methyl benzoyl) benzoic acid

The invention relates to a [...] intermediate 2 - methyl - 4 - N - (2 - methyl benzoyl) benzoic acid for the preparation of the new method, the method to 3 - methylaniline as the starting material, acetate acylation, cyano, cyano hydrolysis, the amidation reaction to obtain the intermediate 2 - methyl - 4 - N - (2 - methyl benzoyl) benzoic acid. The material of the invention is easy to obtain, mild reaction conditions, high yield, does not need special equipment, without the use of highly toxic or an expensive reagent, low cost, convenient to industrial production.

Efficient indoles and anilines syntheses employing tert-butyl sulfinamide as ammonia surrogate

tert-Butyl sulfinamide is an ammonia equivalent for the palladium-catalyzed amination of aryl bromides and aryl chlorides. Using these amine derivatives, it has been observed that indoles and anilines with sensitive functional groups can be readily prepared. This surrogate has also been used for the synthesis of indoles from 2-halophenols using palladium catalyzed cross coupling reaction as the key step.

2-ARYL- AND 2-HETEROARYLTHIAZOLYL COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF

The present invention discloses fused bicyclic 2-aryl- or 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumo