72130-68-8Relevant articles and documents
Propionic Acid Derivatives and Methods of Use Thereof
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Paragraph 1811; 1813, (2018/11/21)
Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.
Heterocyclic Compounds as MEK Inhibitors
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Page/Page column 18, (2009/12/02)
The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.
Annulation of heterocyclic secondary enamines with dicarboxylic acid dichlorides, an unexpected ring size effect
Cheng, Ying,Yang, Hai-Bo,Huang, Zhi-Tang,Wang, Mei-Xiang
, p. 1757 - 1759 (2007/10/03)
Under very mild conditions heterocyclic secondary enamines react efficiently with malonyl chloride to produce hydroxylated 2-pyridinone-fused heterocycles. The reactions of enamines with oxalyl chloride, however, afford varied products depending upon the heterocyclic structure of the enamine. Whilst a C-acylated enamine and a lactam-fused heterocycle were obtained from the reaction of the five- and seven-membered heterocyclic enamines, respectively, the six-membered heterocyclic enamine gave 2-oxo-5,6,7,8-tetrahydro-2H-pyrido[3,2-b]pyran. The reaction mechanisms are discussed.