72141-44-7

Basic information

• Product Name: 4-CHLORO-2-METHOXY-PYRIDINE
• Synonyms: IFLAB-BB F2108-0069;2-METHOXY-4-CHLORO-PYRIDINE;4-CHLORO-2-METHOXY-PYRIDINE;4-chloro-methoxypridine;Pyridine, 4-chloro-2-methoxy-
• CAS NO: 72141-44-7
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• Product Categories: Pyridine;Boronic Acid;Pyridine Series;Heterocycle-Pyridine series
• Mol File: 72141-44-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 26℃
• Boiling Point: 177℃
• Flash Point: 61℃
• Appearance: /
• Density: 1.210
• Vapor Pressure: 1.424mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• PKA: 3.66±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-2-METHOXY-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-METHOXY-PYRIDINE(72141-44-7)
• EPA Substance Registry System: 4-CHLORO-2-METHOXY-PYRIDINE(72141-44-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 72141-44-7(Hazardous Substances Data)

Usage

Description

4-Chloro-2-methoxy-pyridine is an organic compound with the molecular formula C6H6ClNO2. It is a heterocyclic compound featuring a pyridine ring with a chlorine atom at the 4th position and a methoxy group at the 2nd position. 4-CHLORO-2-METHOXY-PYRIDINE is known for its reactivity and is commonly used as a building block in the synthesis of various pharmaceuticals and chemical compounds.

Uses

Used in Chemical Synthesis:
4-Chloro-2-methoxy-pyridine is used as a reagent for the preparation of cyclopalladated ferrocenylimines. These ferrocenylimines serve as efficient catalysts in the synthesis of arylboronate esters, which are important intermediates in organic chemistry and have applications in the production of pharmaceuticals, agrochemicals, and advanced materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-chloro-2-methoxy-pyridine is utilized as a key intermediate in the synthesis of various drug molecules. Its unique structure allows for further functionalization and modification, making it a versatile building block for the development of new therapeutic agents.
Used in Catalyst Development:
4-Chloro-2-methoxy-pyridine is also used in the development of novel catalysts for various chemical reactions. Its presence in cyclopalladated ferrocenylimines enhances the catalytic activity and selectivity of these catalysts, leading to improved reaction efficiency and reduced environmental impact.

InChI:InChI=1/C6H6ClNO/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3

Upstream product

• 26452-80-2 2,4-dichloropyridine 
• 124-41-4 sodium methylate 
• 40673-25-4 4-chloro-2-hydroxypyridine 
• 74-88-4 methyl iodide 
• 851607-23-3 2-methoxy-pyridin-4-ylmagnesium chloride 
• 98197-72-9 (2-iodo-pyridin-4-yl)-dimethyl-amine 

Downstream Products

• 408502-23-8 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 1312350-29-0 (3R,4S)-N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]-N-cyclopropyl-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-piperidine-3-carboxamide 
• 1312350-23-4 (3R,4S)-1-(tert-butoxycarbonyl)-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid 
• 1312350-26-7 tert-butyl (3R,4S)-3-{[[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl](cyclopropyl)amino]carbonyl}-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-1-carboxylate 
• 1312350-32-5 (3R,4S)-N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]-N-cyclopropyl-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-piperidine-3-carboxamide hydrochloride 
• 1008451-58-8 4-chloro-2-methoxynicotinic aldehyde 

Relevant articles and documents

Novel synthesis method for ortho-alkane superseded pyridine

The invention relates to a novel synthesis method for ortho-alkane superseded pyridine. According to the method, ortho halogenated pyridine serves as raw materials, the ortho halogenated pyridine and corresponding alcohol react to obtain the ortho-alkane superseded pyridine under the action of sodium hydroxide. The reaction has universality for the ortho halogenated pyridine, and the method is simple and practical. Influence of consumption of the sodium hydroxide on mono-substitution and di-substitution in the reaction is inspected, alkoxy mono-substitution products and alkoxy di-substitution production are acquired, and a novel simply-operated, economical and favorable process for synthesis ortho-alkane superseded pyridine is provided.

ANTI-FIBROTIC PYRIDINONES

Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

AZETIDINES AND CYCLOBUTANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS

The invention relates to compounds of formula (I) wherein R, R0, R1, m, n and X1 to X4 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.