7217-84-7

Basic information

• Product Name: L-Cysteine, N-benzoyl-
• Synonyms: N-(phenylcarbonyl)-L-cysteine
• CAS NO: 7217-84-7
• Molecular Formula: C₁₀H₁₁NO₃S
• Molecular Weight: 225.268
• Mol File: 7217-84-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 486.7 °C at 760 mmHg
• Flash Point: 248.1 °C
• Density: 1.31 g/cm³
• CAS DataBase Reference: L-Cysteine, N-benzoyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Cysteine, N-benzoyl-(7217-84-7)
• EPA Substance Registry System: L-Cysteine, N-benzoyl-(7217-84-7)

Safety Data

• Hazardous Substances Data: 7217-84-7(Hazardous Substances Data)

Usage

General Description

L-Cysteine, N-benzoyl- is a chemical compound made up of the amino acid L-cysteine and benzoyl groups. It is commonly used as a building block in the synthesis of peptides and proteins, as well as in the production of pharmaceuticals and cosmetics. L-Cysteine, N-benzoyl- is also used as a reducing agent and antioxidant in food processing, where it helps to improve the texture and shelf life of various products. Additionally, it has been studied for its potential therapeutic applications in treating conditions such as inflammation, oxidative stress, and neurodegenerative diseases. However, it is important to note that L-Cysteine, N-benzoyl- may cause skin and respiratory irritation, and should be handled with care in laboratory and manufacturing settings.

Upstream product

• 52-90-4 L-Cysteine 
• 98-88-4 benzoyl chloride 
• 100-47-0 benzonitrile 
• 134861-13-5 N-(benzoylsulfide)benzamide 
• 4231-62-3 1-benzoyl-1H-benzotriazole 
• 7218-05-5 DL-N-benzoylcysteine 
• 25129-20-8 N,N′-dibenzoyl-L-cysteine 

Downstream Products

• 100143-29-1 N-benzoyl-S-cyanomethyl-L-cysteine 

Relevant articles and documents

1,3-Thiazines, XXIX: The applicability of cystein derivatives in the synthesis of 5-aminotetrahydro-1,3-thiazines

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Comparative reactivity analysis of small-molecule thiol surrogates

Targeted covalent inhibitors represent an increasingly popular approach to modulate challenging drug targets. Since covalent and non-covalent interactions are both contributing to the affinity of these compounds, evaluation of their reactivity is a key-step to find feasible warheads. There are well-established HPLC- and NMR-based kinetic assays to tackle this task, however, they use a variety of cysteine-surrogates including cysteamine, cysteine or acetyl-cysteine and GSH. The diverse nature of the thiol sources often makes the results incomparable that prevents compiling a comprehensive knowledge base for the design of covalent inhibitors. To evaluate kinetic measurements from different sources we performed a comparative analysis of the different thiol surrogates against a designed set of electrophilic fragments equipped with a range of warheads. Our study included seven different thiol models and 13 warheads resulting in a reactivity matrix analysed thoroughly. We found that the reactivity profile might be significantly different for various thiol models. Comparing the different warheads, we concluded that – in addition to its human relevance - glutathione (GSH) provided the best estimate of reactivity with highest number of true positives identified.

Medium buffer effects on the condensation of l -cysteine and aryl nitriles to (R)-2-Aryl-4,5-dihydrothiazole-4-carboxylic acids

The condensation of l-cysteine and aryl nitriles to (R)-2-aryl-4,5- dihydrothiazole-4-carboxylic acids in buffered media was reinvestigated. Pure products (yields of 58-95%; up to 99% ee) were obtained in a NaHCO 3/NaOH-buffered aqueous alcoholic medium. Georg Thieme Verlag Stuttgart New York.