72351-49-6

Basic information

• Product Name: 1-BENZYLPYRROLIDINE-3-CARBALDEHYDE
• Synonyms: 1-BENZYLPYRROLIDINE-3-ALDEHYDE;1-BENZYLPYRROLIDINE-3-CARBALDEHYDE;1-BENZYL-3-FORMYL-PYRROLIDINE;1-Boc-pyrrolidine-3-carbaldehyde;1-Benzyl-3-pyrrolidinecarboxaldehyde;N-Benzylpyrrolidine-3-carboxaldehyde
• CAS NO: 72351-49-6
• Molecular Formula: C12H15NO
• Molecular Weight: 189.25
• Product Categories: pharmacetical
• Mol File: 72351-49-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 281℃
• Flash Point: 98℃
• Appearance: /
• Density: 1.149
• Vapor Pressure: 0.00373mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 1-BENZYLPYRROLIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYLPYRROLIDINE-3-CARBALDEHYDE(72351-49-6)
• EPA Substance Registry System: 1-BENZYLPYRROLIDINE-3-CARBALDEHYDE(72351-49-6)

Safety Data

• Hazardous Substances Data: 72351-49-6(Hazardous Substances Data)

Usage

General Description

1-Benzylpyrrolidine-3-carbaldehyde is a chemical compound with the molecular formula C13H15NO. It is a yellow to light brown liquid with a sweet, floral odor. 1-BENZYLPYRROLIDINE-3-CARBALDEHYDE is commonly used in the synthesis of pharmaceuticals and agrochemicals. It is also used as a flavor and fragrance ingredient in the cosmetic and food industries. Additionally, 1-Benzylpyrrolidine-3-carbaldehyde has potential applications in organic synthesis, particularly in the production of various types of heterocycles and biologically active compounds. It is important to handle this chemical with caution, as it can be harmful if inhaled, ingested, or comes into contact with the skin or eyes.

InChI:InChI=1/C12H15NO/c14-10-12-6-7-13(9-12)8-11-4-2-1-3-5-11/h1-5,10,12H,6-9H2

Upstream product

• 71725-74-1 methyl 1-benzyl-2-oxo-pyrrolidine-3-carboxylate 
• 5731-17-9 1-(Phenylmethyl)-3-pyrrolidinemethanol 

Relevant articles and documents

Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil

A series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment of Alzheimer's disease, were designed and synthesised based upon previously unexplored chemical space surrounding the molecular skeleton of the drug donepezil, which is currently used for the management of mild to severe Alzheimer's disease. Two series of analogues were prepared, the first looking at the replacement of the piperidine ring in donepezil with different sized saturated N-containing ring systems and the second looking at the introduction of different linkers between the indanone and piperidine rings in donepezil. The most active analogue 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl 1-benzylpiperidine-4-carboxylate (67) afforded an in vitro IC50value of 0.03 ± 0.07 μM against acetylcholinesterase with no cytotoxicity observed (IC50of >100 μM, SH-SY5Y cell line). In comparison donepezil had an IC50of 0.05 ± 0.06 μM and an observed cytotoxicity IC50of 15.54 ± 1.12 μM. Molecular modelling showed a strong correlation between activity and in silico binding in the active site of acetylcholinesterase.

Src kinase inhibitor compounds

Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.