72435-94-0

Basic information

• Product Name: (2S)-1-(2-nitrobenzoyl)pyrrolidine-2-carbaldehyde
• Synonyms: (S)-1-(2-Nitrobenzoyl)-2-pyrrolidinecarboxaldehyde; 2-Pyrrolidinecarboxaldehyde, 1-(2-nitrobenzoyl)-, (S)-
• CAS NO: 72435-94-0
• Molecular Formula: C₁₂H₁₂N₂O₄
• Molecular Weight: 248.2347
• Mol File: 72435-94-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 452.7°C at 760 mmHg
• Flash Point: 227.6°C
• Density: 1.416g/cm³
• Vapor Pressure: 2.2E-08mmHg at 25°C
• Refractive Index: 1.661
• CAS DataBase Reference: (2S)-1-(2-nitrobenzoyl)pyrrolidine-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1-(2-nitrobenzoyl)pyrrolidine-2-carbaldehyde(72435-94-0)
• EPA Substance Registry System: (2S)-1-(2-nitrobenzoyl)pyrrolidine-2-carbaldehyde(72435-94-0)

Safety Data

• Hazardous Substances Data: 72435-94-0(Hazardous Substances Data)

Upstream product

• 105089-64-3 N-(2-nitrobenzoyl)-L-proline methyl ester 
• 72435-93-9 (S)-N-(2-nitrobenzyl)-pyrrolidine-2-carbinol 
• 610-14-0 2-nitrobenzyl chloride 
• 18877-33-3 (S)-1-(2-nitrobenzoyl)pyrrolidine-2-carboxylic acid 
• 552-16-9 ortho-nitrobenzoic acid 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 

Downstream Products

• 176387-45-4 (S)-1-(2-Nitro-thiobenzoyl)-pyrrolidine-2-carbothioaldehyde 
• 166451-13-4 1-(2'-azidobenzoyl)pyrrolidine-2-carbaldehyde 
• 105089-66-5 (2S)-N-(2-aminobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 72435-89-3 (11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one 
• 105089-65-4 (2S)-N-(2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal 

Relevant articles and documents

Conversion of amines to imines employing Polymer-Supported Sulfoxide (PSS) and Polymer-Supported Perruthenate (PSP): Synthesis of pyrrolo[2,1-c][1,4] benzodiazepines

An efficient method for the oxidation of secondary amines to the corresponding imines has been developed by employing polymer-supported reagents. This protocol has been extended for the generation of a combinatorial library of substituted pyrrolo[2,1-c][1,4]benzodiazepine derivatives and provides a rapid and clean preparation avoiding conventional purification techniques.

An efficient synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics via reductive cyclization

A new and convenient one-pot synthesis of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) ring system has been achieved by a reductive cyclization employing N,N-dimethylhydrazine and FeCl3.6H2O in good yields.

A new facile procedure for the preparation of pyrrolo[2,1-c][1,4]benzodiazepines : Synthesis of the antibiotic DC-81 and its thio analogue

An efficient synthesis of the imine form of the pyrrolo[2,1-c][1,4] benzodiazepine ring system based on a new reductive cyclization procedure is described. The naturally occuring antibiotic DC-81(5c) and its 5-thio analogue (7c) have also been synthesized to illustrate the usefulness of this methodology.