7244-79-3

Basic information

• Product Name: Benzene, 1-(3-methylbutoxy)-4-nitro-
• CAS NO: 7244-79-3
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.245
• Mol File: 7244-79-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(3-methylbutoxy)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(3-methylbutoxy)-4-nitro-(7244-79-3)
• EPA Substance Registry System: Benzene, 1-(3-methylbutoxy)-4-nitro-(7244-79-3)

Safety Data

• Hazardous Substances Data: 7244-79-3(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 10422-35-2 1-bromo-2-methyl-butane 
• 123-51-3 i-Amyl alcohol 
• 701-57-5 1-methylthio-4-nitro-benzene 
• 2976-30-9 1-methanesulfonyl-4-nitrobenzene 
• 107-82-4 i-pentyl bromide 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 5198-05-0 4-(3-methylbutoxy)aniline 
• 22136-24-9 N,N'-Bis--thiocarbanilid 
• 22188-57-4 N--N'--thiocarbanilid 
• 910-86-1 isoxyl 
• 4849-28-9 1,3-bis(4-(isopentyloxy)phenyl)urea 
• 81928-78-1 N-(4-(isopentyloxy)phenyl)acetamide 

Relevant articles and documents

Discriminating non-ylidic carbon-sulfur bond cleavages of sulfonium ylides for alkylation and arylation reactions

A sulfonium ylide participated alkylation and arylation under transition-metal free conditions is described. The disparate reaction pattern allowed the separate activation of non-ylidic S-alkyl and S-aryl bond. Under acidic conditions, sulfonium ylides serve as alkyl cation precursors which facilitate the alkylations. While under alkaline conditions, cleavage of non-ylidic S-aryl bond produces O-arylated compounds efficiently. The robustness of the protocols were established by the excellent compatibility of wide variety of substrates including carbohydrates.

Chromatography-Free Multicomponent Synthesis of Thioureas Enabled by Aqueous Solution of Elemental Sulfur

The development of a new three-component chromatography-free reaction of isocyanides, amines and elemental sulfur allowed us the straightforward synthesis of thioureas in water. Considering a large pool of organic and inorganic bases, we first optimized the preparation of aqueous polysulfide solution from elemental sulfur. Using polysulfide solution, we were able to omit the otherwise mandatory chromatography, and to isolate the crystalline products directly from the reaction mixture by a simple filtration, retaining the sulfur in the solution phase. A wide range of thioureas synthesized in this way confirmed the reasonable substrate and functional group tolerance of our protocol.

Synthesis and biological evaluation of novel IM3829 (4-(2-cyclohexylethoxy)aniline) derivatives as potent radiosensitizers

Nuclear factor-erythroid 2-related factor 2 (Nrf2) regulates the expression of over 200 genes of antioxidant and phase II drug-metabolizing enzymes, and is highly expressed in non-small cell lung cancer (NSCLC). Nine derivatives of 4-(2-cyclohexylethoxy)aniline were designed. Our previous study demonstrated that IM3829 increases radiosensitivity of several lung cancer cells in vitro and in vivo. Here, biological effects of IM3829 derivatives (2a-2i) were evaluated. Compound 2g derivative effectively inhibits mRNA and protein expression of Nrf2 and HO-1. In addition, we observed over two fold enhancement in IR-induced cell death, from 2.90 ± 0.22 to 6.02 ± 0.87, in H1299 cancer cell-line. Among the nine derivatives, compound 2g derivative exhibited the highest enhancement of radiosensitizing effect via inhibition of Nrf2 activity.