72449-42-4 Usage
Description
(S)-2-((TERT-BUTOXYCARBONYL)AMINO)-5-(DIMETHYLAMINO)-5-OXOPENTANOIC ACID is a synthetic organic compound with a complex chemical structure. It is a derivative of pentanoic acid, containing a tert-butoxycarbonyl (Boc) protected amino group at one end and a dimethylamino group at the other end. (S)-2-((TERT-BUTOXYCARBONYL)AMINO)-5-(DIMETHYLAMINO)-5-OXOPENTANOIC ACID is commonly used as a reagent in organic chemistry for the protection of amino groups in peptide synthesis and is a crucial intermediate in the synthesis of biologically active peptides and pharmaceuticals.
Used in Pharmaceutical Industry:
(S)-2-((TERT-BUTOXYCARBONYL)AMINO)-5-(DIMETHYLAMINO)-5-OXOPENTANOIC ACID is used as a crucial intermediate for the synthesis of biologically active peptides and pharmaceuticals. Its unique structure and reactivity make it valuable in the development of new drugs and therapeutic agents.
Used in Organic Chemistry:
(S)-2-((TERT-BUTOXYCARBONYL)AMINO)-5-(DIMETHYLAMINO)-5-OXOPENTANOIC ACID is used as a reagent for the protection of amino groups in peptide synthesis. This allows for the controlled formation of peptide bonds and the synthesis of complex peptide structures.
Check Digit Verification of cas no
The CAS Registry Mumber 72449-42-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,4,4 and 9 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 72449-42:
(7*7)+(6*2)+(5*4)+(4*4)+(3*9)+(2*4)+(1*2)=134
134 % 10 = 4
So 72449-42-4 is a valid CAS Registry Number.
72449-42-4Relevant articles and documents
Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase.
Ramtohul, Yeeman K,James, Michael N G,Vederas, John C
, p. 3169 - 3178 (2007/10/03)
Hepatitis A virus (HAV) 3C enzyme is a picornaviral cysteine proteinase involved in the processing of the initially synthesized viral polyprotein and is therefore important for viral maturation and infectivity. Although it is a cysteine proteinase, this enzyme has a topology similar to those of the chymotrypsin-like serine proteinases. Since the enzyme recognizes peptide substrates with a glutamine residue at the P(1) site, a number of ketone-containing glutamine compounds analogous to nanomolar inhibitors of cathepsin K were synthesized and tested for inhibition against HAV 3C proteinase. In addition, a 3-azetidinone scaffold was incorporated into the glutamine fragment but gave only modest inhibition. However, introduction of a phthalhydrazido group alpha to the ketone moiety gave significantly better inhibitors with IC(50) values ranging from 13 to 164 microM, presumably due to the effect of intramolecular hydrogen bonding to the ketone. In addition, the tetrapeptide phthalhydrazide 24 was found to be a competitive reversible inhibitor (K(i) = 9 x 10(-6) M) and also showed no loss of inhibitory potency in the presence of dithiothreitol.
