7250-52-4

Basic information

• Product Name: 4-Methyl-3-pyridinecarboxamide
• Synonyms: 3-Pyridinecarboxamide,4-methyl-(9CI);4-Methyl-3-pyridinecarboxamide;4-Methylnicotinamide;4-Methylpyridine-3-carboxamide;3-PyridinecarboxaMide, 4-Methyl-
• CAS NO: 7250-52-4
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15
• Product Categories: AMIDE
• Mol File: 7250-52-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 294.1 °C at 760 mmHg
• Flash Point: 131.6 °C
• Appearance: /
• Density: 1.157 g/cm³
• Vapor Pressure: 0.00166mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 14.85±0.50(Predicted)
• CAS DataBase Reference: 4-Methyl-3-pyridinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-3-pyridinecarboxamide(7250-52-4)
• EPA Substance Registry System: 4-Methyl-3-pyridinecarboxamide(7250-52-4)

Safety Data

• Hazardous Substances Data: 7250-52-4(Hazardous Substances Data)

Usage

Uses

4-Methylnicotinamide, is an intermediate in the synthesis of various pharmaceutical compounds. It can be used in the preparation of various pyrimidine and pyridine derivatives, possessing antitumor cell activity.

InChI:InChI=1/C7H8N2O/c1-5-2-3-9-4-6(5)7(8)10/h2-4H,1H3,(H2,8,10)

Upstream product

• 5444-01-9 3-cyano-4-methylpyridine 
• 67-56-1 methanol 
• 98-92-0 nicotinamide 

Downstream Products

• 3430-27-1 3-amino-4-methylpyridine 
• 1443-42-1 ((4-methylpyridin-3-yl)methyl)amine 
• 19355-10-3 1-benzyl-4-methyl-1,4-dihydronicotinamide 
• 5444-01-9 3-cyano-4-methylpyridine 

Relevant articles and documents

Method for preparing amide compounds by using supported metal oxide catalytic material

The invention relates to a catalyst for preparing amide compounds, and aims to provide a method for preparing amide compounds by using a supported metal oxide catalytic material. The method comprisesthe following steps: uniformly mixing a solvent, water, an organic nitrile compound and the catalytic material; performing a reaction at 50-180 DEG C for 0.5-48 h; and hydrating and converting the organic nitrile compound into the corresponding amide compounds through the catalytic hydration effect of the catalyst in the reaction process. Adsorption and activation of the catalytic material to water molecules can be effectively regulated by regulating metal components loaded on the catalytic material and a catalytic material carrier, so that important amide compounds in chemical and agricultural processes are efficiently prepared. The provided method for preparing the amide compounds is effect, and has the advantages of high atom utilization rate in the reaction process, low reaction temperature, no additional reaction assistant in the synthesis process, no generation of toxic or harmful byproducts after the reaction, and green and environment-friendly synthesis process.

Facile and efficient synthesis of 4-alkyl derivatives of 3-carbamoyl- and 3,5-dicarbamoylpyridines as nicotinamide mimetics

Nicotinamide plays a key role in many biological processes and, as a consequence, its derivatives could be attractive for the synthesis of biologically active compounds. Here a rapid and efficient way of preparing alkyl derivatives of nicotinamide, precisely, 4-alkyl-3-carbamoylpyridine and 4-alkyl-3,5-dicarbamoylpyridine is reported. The synthetic route developed adopts mild reaction conditions and produces target compounds in higher yields compared with methods described in literature. Georg Thieme Verlag Stuttgart · New York.

Method for the preparation of 3-amino-2-chloro-4-methylpyridines

A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of the formula: STR1 wherein R is alkyl of from one to three carbon atoms, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.