725707-40-4Relevant articles and documents
Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds
Skinner-Adams, Tina S.,Lowther, Jonathan,Teuscher, Franka,Stack, Colin M.,Grembecka, Jolanta,Mucha, Artur,Kafarski, Pawel,Trenholme, Katharine R.,Dalton, John P.,Gardiner, Donald L.
, p. 6024 - 6031 (2007)
Previous studies have pinpointed the M17 leucyl aminopeptidase of Plasmodium falciparum (PfLAP) as a target for the development of new antimalarials. This metallo-exopeptidase functions in the terminal stages of hemoglobin digestion and is inhibited by be
Synthesis and activity of phosphinic tripeptide inhibitors of cathepsin C
Mucha, Artur,Pawelczak, Malgorzata,Hurek, Jozef,Kafarski, Pawel
, p. 3113 - 3116 (2007/10/03)
Phosphinic tripeptide analogues Gly-Xaaψ[P(O)(OH)CH2]-Gly have been developed as inhibitors of cathepsin C (DPP I), a lysosomal, papain-like cysteine protease. The target compounds were synthesised by addition of methyl acrylate to the appropri
