726198-18-1 Usage
General Description
1-BOC-4-CYANO-4-(2-FLUOROPHENYL)-PIPERIDINE is a chemical compound with the molecular formula C19H23FN2O2. It is a piperidine derivative that is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. The compound contains a BOC (tert-butoxycarbonyl) protecting group, a cyano group, and a fluorophenyl group, which contribute to its reactivity and biological activity. 1-BOC-4-CYANO-4-(2-FLUOROPHENYL)-PIPERIDINE is often used in organic chemistry research and drug development due to its versatile nature and potential applications in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 726198-18-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,2,6,1,9 and 8 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 726198-18:
(8*7)+(7*2)+(6*6)+(5*1)+(4*9)+(3*8)+(2*1)+(1*8)=181
181 % 10 = 1
So 726198-18-1 is a valid CAS Registry Number.
726198-18-1Relevant articles and documents
Erratum: A new synthesis of spiropyrrolidine-tetralones via an unexpected formal ring-contraction of 4-disubstituted piperidine to 3-disubstituted pyrrolidine (Tetrahedron Letters (2010) 51 (6415-6417))
Bandarage, Upul K.,Davies, Robert J.
, p. 469 - 469 (2011)
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A convenient synthesis of 1′-H-spiro-(indoline-3,4′-piperidine) and its derivatives
Xie, Jian-Shu,Huang, Charles Q.,Fang, Yan-Yan,Zhu, Yun-Fei
, p. 4875 - 4878 (2007/10/03)
A simple synthetic route has been developed to prepare 1′-H- spiro(indoline-3,4′-piperidine) (1d). Dialkylation of 2- fluorophenylacetonitrile with N-(tert-butyloxycarbonyl)-bis(2-chloroethyl)amine (5) gave 6. Deprotection of Boc followed by cyclization resulted 1d in 67% overall yield. Selective Boc or Cbz protection of 1′-N gave 1a or 1b with 90 and 85% yield, respectively. Thus, in a five-step procedure, 1a and 1b were synthesized from commercially available reagents in over 50% overall yield. All 3 compounds (1a, 1b and 1d) can be utilized as templates to synthesize compounds for GPCR targets.
